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Reaction Details
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TargetAdenosine receptor A1
LigandBDBM50316993
Substrate/Competitorn/a
Meas. Tech.ChEMBL_630131
Ki 85±n/a nM
Citation Shook, BCRassnick, SHall, DRupert, KCHeintzelman, GRHansen, KChakravarty, DBullington, JLScannevin, RHMagliaro, BWestover, LCarroll, KLampron, LRussell, RBranum, SWells, KDamon, SYouells, SLi, XOsbourne, MDemarest, KTang, YRhodes, KJackson, PF Methylene amine substituted arylindenopyrimidines as potent adenosine A(2A)/A(1) antagonists. Bioorg Med Chem Lett20:2864-7 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Adenosine receptor A1
Name:Adenosine receptor A1/Alpha-2A adrenergic receptor
Synonyms:A1 adenosine receptor (hA1) | A1AR | ADENOSINE A1 | ADORA1 | Adenosine A1 receptor (A1AR) | Adenosine A1-receptor | Adenosine receptor A1 (A1) | Adenosine receptor A1 (hA1) | Adenosine transporter (AdT)
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:36520.92
Organism:Homo sapiens (Human)
Description:P30542
Residue:326
Sequence:
MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGA
LVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVT
PRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYM
VYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALIL
FLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFL
KIWNDHFRCQPAPPIDEDLPEERPDD
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  Blast E-value cutoff:
BDBM50316993
NameBDBM50316993
Synonyms:2-amino-4-(4-fluorophenyl)-9-(pyrrolidin-1-ylmethyl)-5H-indeno[1,2-d]pyrimidin-5-one | CHEMBL1087710
TypeSmall organic molecule
Emp. Form.C22H19FN4O
Mol. Mass.374.4109
SMILESNc1nc2-c3c(cccc3CN3CCCC3)C(=O)c2c(n1)-c1ccc(F)cc1
Structure
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