Reaction Details Report a problem with these data
Target
Adenosine receptor A2a
Ligand
BDBM50317020
Substrate
n/a
Meas. Tech.
ChEMBL_630130 (CHEMBL1113721)
Ki
7.9±n/a nM
Citation
 Shook, BC; Rassnick, S; Hall, D; Rupert, KC; Heintzelman, GR; Hansen, K; Chakravarty, D; Bullington, JL; Scannevin, RH; Magliaro, B; Westover, L; Carroll, K; Lampron, L; Russell, R; Branum, S; Wells, K; Damon, S; Youells, S; Li, X; Osbourne, M; Demarest, K; Tang, Y; Rhodes, K; Jackson, PF Methylene amine substituted arylindenopyrimidines as potent adenosine A(2A)/A(1) antagonists. Bioorg Med Chem Lett 20:2864-7 (2010) [PubMed]  Article 
Target
Name:
Adenosine receptor A2a
Synonyms:
A2A adenosine receptor (hA2A) | AA2AR_HUMAN | ADENOSINE A2 | ADENOSINE A2a | ADORA2 | ADORA2A | Adenosine A2A receptor (A2AAR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44716.46
Organism:
Homo sapiens (Human)
Description:
P29274
Residue:
412
Sequence:
MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNGYALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS
  
Inhibitor
Name:
BDBM50317020
Synonyms:
9-((4-acetylpiperazin-1-yl)methyl)-2-amino-4-phenyl-5H-indeno[1,2-d]pyrimidin-5-one | CHEMBL1087819
Type:
Small organic molecule
Emp. Form.:
C24H23N5O2
Mol. Mass.:
413.4717
SMILES:
CC(=O)N1CCN(Cc2cccc3C(=O)c4c(nc(N)nc4-c4ccccc4)-c23)CC1
Structure:
Search PDB for entries with ligand similarity: