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Target
Ribosyldihydronicotinamide dehydrogenase [quinone]
Ligand
BDBM50008352
Substrate
n/a
Meas. Tech.
ChEMBL_630842 (CHEMBL1109212)
IC50
50±n/a nM
Citation
 Nolan, KA; Humphries, MP; Bryce, RA; Stratford, IJ Imidazoacridin-6-ones as novel inhibitors of the quinone oxidoreductase NQO2. Bioorg Med Chem Lett 20:2832-6 (2010) [PubMed]  Article 
Target
Name:
Ribosyldihydronicotinamide dehydrogenase [quinone]
Synonyms:
Metallothionein-3 | NMOR2 | NQO2 | NQO2_HUMAN | NRH dehydrogenase [quinone] 2 | NRH:quinone oxidoreductase 2 | QR2 | Quinone reductase 2 | Quinone reductase 2 (NQO2) | Ribosyldihydronicotinamide dehydrogenase [quinone]
Type:
Protein
Mol. Mass.:
25917.25
Organism:
Homo sapiens (Human)
Description:
P16083
Residue:
231
Sequence:
MAGKKVLIVYAHQEPKSFNGSLKNVAVDELSRQGCTVTVSDLYAMNLEPRATDKDITGTLSNPEVFNYGVETHEAYKQRSLASDITDEQKKVREADLVIFQFPLYWFSVPAILKGWMDRVLCQGFAFDIPGFYDSGLLQGKLALLSVTTGGTAEMYTKTGVNGDSRYFLWPLQHGTLHFCGFKVLAPQISFAPEIASEEERKGMVAAWSQRLQTIWKEEPIPCTAHWHFGQ
  
Inhibitor
Name:
BDBM50008352
Synonyms:
5-(2-(dimethylamino)ethylamino)-8-hydroxy-1-methyl-6H-imidazo[4,5,1-de]acridin-6-one | 5-(2-Dimethylamino-ethylamino)-8-hydroxy-1-methyl-2,10b-diaza-aceanthrylen-6-one(2.0MHCl.2.0MH2O) | CHEMBL124373 | NSC-637991
Type:
Small organic molecule
Emp. Form.:
C19H20N4O2
Mol. Mass.:
336.3877
SMILES:
CN(C)CCNc1ccc2nc(C)n3c2c1c(=O)c1cc(O)ccc31
Structure:
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