Target
11-beta-hydroxysteroid dehydrogenase 1
Ligand
BDBM50317214
Substrate
n/a
Meas. Tech.
ChEMBL_631347 (CHEMBL1105684)
IC50
0.03±n/a nM
Citation
 Cheng, HHoffman, JLe, PNair, SKCripps, SMatthews, JSmith, CYang, MKupchinsky, SDress, KEdwards, MCole, BWalters, ELoh, CErmolieff, JFanjul, ABhat, GBHerrera, JPauly, THosea, NPaderes, GRejto, P The development and SAR of pyrrolidine carboxamide 11beta-HSD1 inhibitors. Bioorg Med Chem Lett 20:2897-902 (2010) [PubMed]  Article 
Target
Name:
11-beta-hydroxysteroid dehydrogenase 1
Synonyms:
11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1
Type:
Enzyme
Mol. Mass.:
32409.16
Organism:
Homo sapiens (Human)
Description:
P28845
Residue:
292
Sequence:
MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILEFLYSTSYNMDRFINK
  
Inhibitor
Name:
BDBM50317214
Synonyms:
(2R)-N-(adamantan-2-yl)-1-(2-methylpropyl)pyrrolidine-2-carboxamide | CHEMBL1098130
Type:
Small organic molecule
Emp. Form.:
C19H32N2O
Mol. Mass.:
304.4702
SMILES:
CC(C)CN1CCC[C@@H]1C(=O)NC1C2CC3CC(C2)CC1C3 |r,wU:8.9,TLB:18:17:21:14.13.12,18:13:16.17.19:21,THB:11:12:16.17.19:21,12:13:16:19.20.21,12:20:16:14.18.13,(-4.2,-19.79,;-5.1,-21.04,;-6.63,-20.89,;-4.46,-22.45,;-5.36,-23.69,;-6.89,-23.71,;-7.36,-25.17,;-6.12,-26.07,;-4.91,-25.1,;-3.4,-25.61,;-2.05,-24.86,;-3.42,-27.15,;-4.77,-27.89,;-4.78,-29.42,;-6.18,-29.78,;-7.52,-29.28,;-8.71,-30.56,;-7.21,-30.14,;-5.8,-30.71,;-7.22,-28.56,;-6.17,-27.31,;-7.53,-27.8,)|
Structure:
Search PDB for entries with ligand similarity: