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Target11-beta-hydroxysteroid dehydrogenase 1
LigandBDBM50317215
Substrate/Competitorn/a
Meas. Tech.ChEMBL_631347
IC50 0.03±n/a nM
Citation Cheng, HHoffman, JLe, PNair, SKCripps, SMatthews, JSmith, CYang, MKupchinsky, SDress, KEdwards, MCole, BWalters, ELoh, CErmolieff, JFanjul, ABhat, GBHerrera, JPauly, THosea, NPaderes, GRejto, P The development and SAR of pyrrolidine carboxamide 11beta-HSD1 inhibitors. Bioorg Med Chem Lett20:2897-902 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
11-beta-hydroxysteroid dehydrogenase 1
Name:11-beta-hydroxysteroid dehydrogenase 1
Synonyms:11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1)
Type:Enzyme
Mol. Mass.:32409.16
Organism:Homo sapiens (Human)
Description:P28845
Residue:292
Sequence:
MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAH
VVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNH
ITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMV
AAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEE
CALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILEFLYSTSYNMDRFINK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50317215
NameBDBM50317215
Synonyms:(2R)-N-(adamantan-2-yl)-1-(cyclobutylmethyl)pyrrolidine-2-carboxamide | CHEMBL1098131
TypeSmall organic molecule
Emp. Form.C20H32N2O
Mol. Mass.316.4809
SMILESO=C(NC1C2CC3CC(C2)CC1C3)[C@H]1CCCN1CC1CCC1 |r,wU:13.15,TLB:9:8:12:5.4.3,9:4:7.8.10:12,THB:2:3:7.8.10:12,3:4:7:10.11.12,3:11:7:5.9.4,(8.45,-25.87,;7.1,-26.62,;7.08,-28.16,;5.73,-28.91,;5.72,-30.44,;4.32,-30.8,;2.98,-30.3,;1.78,-31.58,;3.29,-31.16,;4.7,-31.73,;3.28,-29.57,;4.33,-28.33,;2.97,-28.81,;5.59,-26.11,;4.38,-27.09,;3.14,-26.18,;3.6,-24.72,;5.13,-24.71,;6.04,-23.46,;5.4,-22.05,;5.96,-20.61,;4.51,-20.07,;3.97,-21.51,)|
Structure
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