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Target
Casein kinase I isoform alpha
Ligand
BDBM50145371
Substrate
n/a
Meas. Tech.
ChEMBL_631604 (CHEMBL1106598)
IC50
>10000±n/a nM
Citation
 Sliman, F; Blairvacq, M; Durieu, E; Meijer, L; Rodrigo, J; Desmaële, D Identification and structure-activity relationship of 8-hydroxy-quinoline-7-carboxylic acid derivatives as inhibitors of Pim-1 kinase. Bioorg Med Chem Lett 20:2801-5 (2010) [PubMed]  Article 
Target
Name:
Casein kinase I isoform alpha
Synonyms:
CK1 | CKI-alpha | CSNK1A1 | Casein Kinase I | Casein kinase 1 alpha (CK1 alpha) | Casein kinase I isoform alpha/delta | KC1A_HUMAN
Type:
Serine/threonine-protein kinase
Mol. Mass.:
38936.59
Organism:
Homo sapiens (Human)
Description:
P48729
Residue:
337
Sequence:
MASSSGSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESKLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQLFRILFRTLNHQYDYTFDWTMLKQKAAQQAASSSGQGQQAQTPTGKQTDKTKSNMKGF
  
Inhibitor
Name:
BDBM50145371
Synonyms:
2-(2,4-Dihydroxy-benzylcarbamoyl)-8-hydroxy-quinoline-7-carboxylic acid | 2-(2,4-dihydroxybenzylcarbamoyl)-8-hydroxyquinoline-7-carboxylic acid | CHEMBL81714
Type:
Small organic molecule
Emp. Form.:
C18H14N2O6
Mol. Mass.:
354.3136
SMILES:
OC(=O)c1ccc2ccc(nc2c1O)C(=O)NCc1ccc(O)cc1O
Structure:
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