Target
Oxysterols receptor LXR-alpha
Ligand
BDBM50317737
Substrate
n/a
Meas. Tech.
ChEMBL_629444 (CHEMBL1105797)
IC50
4.8±n/a nM
Citation
 Ullrich, JWMorris, RBernotas, RCTravins, JMJetter, JUnwalla, RQuinet, ENambi, PFeingold, IHuselton, CEnroth, CWilhelmsson, AGoos-Nilsson, AWrobel, J Synthesis of 4-(3-biaryl)quinoline sulfones as potent liver X receptor agonists. Bioorg Med Chem Lett 20:2903-7 (2010) [PubMed]  Article 
Target
Name:
Oxysterols receptor LXR-alpha
Synonyms:
LXRA | Liver X Receptor alpha (LXR-alpha) | Liver X receptor alpha | Liver X receptor alpha (LXRA) | Liver X receptor alpha (NR1H3) | Liver X, LXR alpha | NR1H3 | NR1H3_HUMAN | Nuclear orphan receptor LXR-alpha | Nuclear receptor subfamily 1 group H member 3
Type:
Enzyme Catalytic Domain
Mol. Mass.:
50403.85
Organism:
Homo sapiens (Human)
Description:
Q13133
Residue:
447
Sequence:
MSLWLGAPVPDIPPDSAVELWKPGAQDASSQAQGGSSCILREEARMPHSAGGTAGVGLEAAEPTALLTRAEPPSEPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLKRQEEEQAHATSLPPRASSPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTPWPMAPDPHSREARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
  
Inhibitor
Name:
BDBM50317737
Synonyms:
3-ethyl-4-(3'-(methylsulfonyl)biphenyl-3-yl)-8-(trifluoromethyl)quinoline | CHEMBL1098403
Type:
Small organic molecule
Emp. Form.:
C25H20F3NO2S
Mol. Mass.:
455.492
SMILES:
CCc1cnc2c(cccc2c1-c1cccc(c1)-c1cccc(c1)S(C)(=O)=O)C(F)(F)F
Structure:
Search PDB for entries with ligand similarity: