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Target
Cathepsin K
Ligand
BDBM50318882
Substrate
n/a
Meas. Tech.
ChEMBL_633770 (CHEMBL1119720)
Ki
4.8±n/a nM
Citation
 Allen, JG; Fotsch, C; Babij, P Emerging targets in osteoporosis disease modification. J Med Chem 53:4332-53 (2010) [PubMed]  Article 
Target
Name:
Cathepsin K
Synonyms:
CATK_HUMAN | CTSK | CTSO | CTSO2 | Cathepsin O | Cathepsin O2 | Cathepsin X
Type:
Enzyme
Mol. Mass.:
36975.68
Organism:
Homo sapiens (Human)
Description:
P43235
Residue:
329
Sequence:
MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM
  
Inhibitor
Name:
BDBM50318882
Synonyms:
4-(2-(4-methylpiperazin-1-yl)thiazol-4-yl)-N-(1-((3S,4R)-2-oxo-4-phenoxyazetidin-3-ylcarbamoyl)cyclohexyl)benzamide | 4-[2-(4-Methyl-piperazin-1-yl)-thiazol-4-yl]-N-[1-((3S,4R)-2-oxo-4-phenoxy-azetidin-3-ylcarbamoyl)-cyclohexyl]-benzamide | CHEMBL367800
Type:
Small organic molecule
Emp. Form.:
C31H36N6O4S
Mol. Mass.:
588.72
SMILES:
CN1CCN(CC1)c1nc(cs1)-c1ccc(cc1)C(=O)NC1(CCCCC1)C(=O)N[C@H]1[C@H](NC1=O)Oc1ccccc1 |r|
Structure:
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