Reaction Details Report a problem with these data
Target
Histone deacetylase 2
Ligand
BDBM50319235
Substrate
n/a
Meas. Tech.
ChEMBL_633817 (CHEMBL1119895)
Ki
44±n/a nM
Citation
 Wang, H; Lim, ZY; Zhou, Y; Ng, M; Lu, T; Lee, K; Sangthongpitag, K; Goh, KC; Wang, X; Wu, X; Khng, HH; Goh, SK; Ong, WC; Bonday, Z; Sun, ET Acylurea connected straight chain hydroxamates as novel histone deacetylase inhibitors: Synthesis, SAR, and in vivo antitumor activity. Bioorg Med Chem Lett 20:3314-21 (2010) [PubMed]  Article 
Target
Name:
Histone deacetylase 2
Synonyms:
Cereblon/Histone deacetylase 2 | HD2 | HDAC2 | HDAC2_HUMAN | Histone deacetylase 2 (HDAC2) | Human HDAC2
Type:
Chromatin regulator; hydrolase; repressor
Mol. Mass.:
55356.54
Organism:
Homo sapiens (Human)
Description:
Q92769
Residue:
488
Sequence:
MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAGAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLGGGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYMEKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEEFSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGTKSEQLSNP
  
Inhibitor
Name:
BDBM50319235
Synonyms:
6-(3-Benzoyl-ureido)-hexanoic acid hydroxyamide | CHEMBL1083439
Type:
Small organic molecule
Emp. Form.:
C14H19N3O4
Mol. Mass.:
293.3184
SMILES:
ONC(=O)CCCCCNC(=O)NC(=O)c1ccccc1
Structure:
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