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Target
Polyamine deacetylase HDAC10
Ligand
BDBM50319209
Substrate
n/a
Meas. Tech.
ChEMBL_633824 (CHEMBL1119902)
Ki
9±n/a nM
Citation
 Wang, H; Lim, ZY; Zhou, Y; Ng, M; Lu, T; Lee, K; Sangthongpitag, K; Goh, KC; Wang, X; Wu, X; Khng, HH; Goh, SK; Ong, WC; Bonday, Z; Sun, ET Acylurea connected straight chain hydroxamates as novel histone deacetylase inhibitors: Synthesis, SAR, and in vivo antitumor activity. Bioorg Med Chem Lett 20:3314-21 (2010) [PubMed]  Article 
Target
Name:
Polyamine deacetylase HDAC10
Synonyms:
HD10 | HDA10_HUMAN | HDAC10 | Histone deacetylase | Histone deacetylase 10 | Human HDAC10
Type:
Chromatin regulator; hydrolase; repressor
Mol. Mass.:
71431.89
Organism:
Homo sapiens (Human)
Description:
Q969S8
Residue:
669
Sequence:
MGTALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEELGLVHSPEYVSLVRETQVLGKEELQALSGQFDAIYFHPSTFHCARLAAGAGLQLVDAVLTGAVQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGLHRILVVDWDVHHGQGIQYLFEDDPSVLYFSWHRYEHGRFWPFLRESDADAVGRGQGLGFTVNLPWNQVGMGNADYVAAFLHLLLPLAFEFDPELVLVSAGFDSAIGDPEGQMQATPECFAHLTQLLQVLAGGRVCAVLEGGYHLESLAESVCMTVQTLLGDPAPPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQDVTAVPMSPSSHSPEGRPPPLLPGGPVCKAAASAPSSLLDQPCLCPAPSVRTAVALTTPDITLVLPPDVIQQEASALREETEAWARPHESLAREEALTALGKLLYLLDGMLDGQVNSGIAATPASAAAATLDVAVRRGLSHGAQRLLCVALGQLDRPPDLAHDGRSLWLNIRGKEAAALSMFHVSTPLPVMTGGFLSCILGLVLPLAYGFQPDLVLVALGPGHGLQGPHAALLAAMLRGLAGGRVLALLEENSTPQLAGILARVLNGEAPPSLGPSSVASPEDVQALMYLRGQLEPQWKMLQCHPHLVA
  
Inhibitor
Name:
BDBM50319209
Synonyms:
6-[3-(4-Bromo-benzoyl)-ureido]-hexanoic acid hydroxyamide | CHEMBL1083086
Type:
Small organic molecule
Emp. Form.:
C14H18BrN3O4
Mol. Mass.:
372.214
SMILES:
ONC(=O)CCCCCNC(=O)NC(=O)c1ccc(Br)cc1
Structure:
Search PDB for entries with ligand similarity: