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Target
Cell division control protein 42 homolog
Ligand
BDBM50319634
Substrate
n/a
Meas. Tech.
ChEMBL_634591 (CHEMBL1117932)
IC50
1300±n/a nM
Citation
 Wu, F; Büttner, FH; Chen, R; Hickey, E; Jakes, S; Kaplita, P; Kashem, MA; Kerr, S; Kugler, S; Paw, Z; Prokopowicz, A; Shih, CK; Snow, R; Young, E; Cywin, CL Substituted 2H-isoquinolin-1-one as potent Rho-Kinase inhibitors. Part 1: Hit-to-lead account. Bioorg Med Chem Lett 20:3235-9 (2010) [PubMed]  Article 
Target
Name:
Cell division control protein 42 homolog
Synonyms:
CDC42 | CDC42_HUMAN | Cell division control protein 42 homolog | G25K GTP-binding protein | cell division cycle 42 (GTP binding protein, 25kDa)
Type:
PROTEIN
Mol. Mass.:
21258.36
Organism:
Homo sapiens (Human)
Description:
ChEMBL_652970
Residue:
191
Sequence:
MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEITHHCPKTPFLLVGTQIDLRDDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSALTQKGLKNVFDEAILAALEPPEPKKSRRCVLL
  
Inhibitor
Name:
BDBM50319634
Synonyms:
CHEMBL1084892 | N-(7-chloro-1-oxo-1,2-dihydroisoquinolin-6-yl)-2-(methylamino)-2-phenylacetamide
Type:
Small organic molecule
Emp. Form.:
C18H16ClN3O2
Mol. Mass.:
341.792
SMILES:
CNC(C(=O)Nc1cc2cc[nH]c(=O)c2cc1Cl)c1ccccc1
Structure:
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