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Target
Large neutral amino acids transporter small subunit 1
Ligand
BDBM50025837
Substrate
n/a
Meas. Tech.
ChEMBL_634759 (CHEMBL1119375)
Ki
55000±n/a nM
Citation
 Matharu, J; Oki, J; Worthen, DR; Smith, QR; Crooks, PA Regiospecific and conformationally restrained analogs of melphalan and DL-2-NAM-7 and their affinities for the large neutral amino acid transporter (system LAT1) of the blood-brain barrier. Bioorg Med Chem Lett 20:3688-91 (2010) [PubMed]  Article 
Target
Name:
Large neutral amino acids transporter small subunit 1
Synonyms:
L-type amino acid transporter 1 | LAT1_RAT | Lat1 | Mpe16 | Slc7a5 | Ta1
Type:
PROTEIN
Mol. Mass.:
55907.74
Organism:
Rattus norvegicus
Description:
ChEMBL_634760
Residue:
512
Sequence:
MAVAGAKRRAVAAPATTAAEEERQAREKMLEARRGDGADPEGEGVTLQRNITLINGVAIIVGTIIGSGIFVTPTGVLKEAGSPGLSLVVWAVCGVFSIVGALCYAELGTTISKSGGDYAYMLEVYGSLPAFLKLWIELLIIRPSSQYIVALVFATYLLKPVFPTCPVPEEAAKLVACLCVLLLTAVNCYSVKAATRVQDAFAAAKLLALALIILLGFIQMGKDIGQGDASNLHQKLSFEGTNLDVGNIVLALYSGLFAYGGWNYLNFVTEEMINPYRNLPLAIIISLPIVTLVYVLTNLAYFTTLSTNQMLTSEAVAVDFGNYHLGVMSWIIPVFVGLSCFGSVNGSLFTSSRLFFVGSREGHLPSILSMIHPQLLTPVPSLVFTCVMTLMYAFSRDIFSIINFFSFFNWLCVALAIIGMMWLRFKKPELERPIKVNLALPVFFILACLFLIAVSFWKTPLECGIGFAIILSGLPVYFFGVWWKNKPKWILQVIFSVTVLCQKLMQVVPQET
  
Inhibitor
Name:
BDBM50025837
Synonyms:
(S)-2-Amino-3-{4-[bis-(2-chloro-ethyl)-amino]-phenyl}-propionic acid | (S)-2-amino-3-(4-(bis(2-chloroethyl)amino)phenyl)propanoic acid | 2-Amino-3-{4-[bis-(2-chloro-ethyl)-amino]-phenyl}-propionic acid | 2-Amino-3-{4-[bis-(2-chloro-ethyl)-amino]-phenyl}-propionic acid (melphalan) | 2-Amino-3-{4-[bis-(2-chloro-ethyl)-amino]-phenyl}-propionic acid(L-PAM) | 2-Amino-3-{4-[bis-(2-chloro-ethyl)-amino]-phenyl}-propionic acid(Melphalan) | 2-amino-3-(4-(bis(2-chloroethyl)amino)phenyl)propanoic acid | 2-amino-3-[4-bis(2-chloroethyl)amino]phenylpropanoic acid | 3-(p-(bis(2-chloroethyl)amino)phenyl)-L-alanine | Alanine Nitrogen Mustard | Alkeran | CB-3025 | CHEMBL852 | L-Sarcolysin | MELPHALAN | Melfalan | Phenylalanine Mustard
Type:
Small organic molecule
Emp. Form.:
C13H18Cl2N2O2
Mol. Mass.:
305.2
SMILES:
N[C@@H](Cc1ccc(cc1)N(CCCl)CCCl)C(O)=O |r|
Structure:
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