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Target
B-cell receptor CD22
Ligand
BDBM50320699
Substrate
n/a
Meas. Tech.
ChEMBL_638728 (CHEMBL1169089)
Kd
2000000±n/a nM
Citation
 Hanashima, S; Sato, K; Naito, Y; Takematsu, H; Kozutsumi, Y; Ito, Y; Yamaguchi, Y Synthesis and binding analysis of unique AG2 pentasaccharide to human Siglec-2 using NMR techniques. Bioorg Med Chem 18:3720-5 (2010) [PubMed]  Article 
Target
Name:
B-cell receptor CD22
Synonyms:
CD22 | CD22_HUMAN | SIGLEC2
Type:
PROTEIN
Mol. Mass.:
95348.60
Organism:
Homo sapiens (Human)
Description:
ChEMBL_727026
Residue:
847
Sequence:
MHLLGPWLLLLVLEYLAFSDSSKWVFEHPETLYAWEGACVWIPCTYRALDGDLESFILFHNPEYNKNTSKFDGTRLYESTKDGKVPSEQKRVQFLGDKNKNCTLSIHPVHLNDSGQLGLRMESKTEKWMERIHLNVSERPFPPHIQLPPEIQESQEVTLTCLLNFSCYGYPIQLQWLLEGVPMRQAAVTSTSLTIKSVFTRSELKFSPQWSHHGKIVTCQLQDADGKFLSNDTVQLNVKHTPKLEIKVTPSDAIVREGDSVTMTCEVSSSNPEYTTVSWLKDGTSLKKQNTFTLNLREVTKDQSGKYCCQVSNDVGPGRSEEVFLQVQYAPEPSTVQILHSPAVEGSQVEFLCMSLANPLPTNYTWYHNGKEMQGRTEEKVHIPKILPWHAGTYSCVAENILGTGQRGPGAELDVQYPPKKVTTVIQNPMPIREGDTVTLSCNYNSSNPSVTRYEWKPHGAWEEPSLGVLKIQNVGWDNTTIACAACNSWCSWASPVALNVQYAPRDVRVRKIKPLSEIHSGNSVSLQCDFSSSHPKEVQFFWEKNGRLLGKESQLNFDSISPEDAGSYSCWVNNSIGQTASKAWTLEVLYAPRRLRVSMSPGDQVMEGKSATLTCESDANPPVSHYTWFDWNNQSLPYHSQKLRLEPVKVQHSGAYWCQGTNSVGKGRSPLSTLTVYYSPETIGRRVAVGLGSCLAILILAICGLKLQRRWKRTQSQQGLQENSSGQSFFVRNKKVRRAPLSEGPHSLGCYNPMMEDGISYTTLRFPEMNIPRTGDAESSEMQRPPPDCDDTVTYSALHKRQVGDYENVIPDFPEDEGIHYSELIQFGVGERPQAQENVDYVILKH
  
Inhibitor
Name:
BDBM50320699
Synonyms:
(2R,4S,5R,6S)-5-acetamido-2-((2S,3R,4S,5S,6R)-2-((2R,3R,4R,5R,6R)-4,5-dihydroxy-2-(hydroxymethyl)-6-(2-(trimethylsilyl)ethoxy)tetrahydro-2H-pyran-3-yloxy)-3,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-4-yloxy)-4-((3S,4R,5S)-4-((2S,3R,4R,5S)-5-((R)-1,2-dihydroxyethyl)-3,4-dihydroxytetrahydrofuran-2-yloxy)-3,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yloxy)-6-((1R,2R)-1,2,3-trihydroxypropyl)tetrahydro-2H-pyran-2-carboxylic acid | CHEMBL1163267
Type:
Small organic molecule
Emp. Form.:
C40H71NO29Si
Mol. Mass.:
1058.0665
SMILES:
CC(=O)N[C@@H]1[C@H](C[C@@](O[C@H]2[C@@H](O)[C@@H](CO)O[C@@H](O[C@@H]3[C@@H](CO)O[C@@H](OCC[Si](C)(C)C)[C@H](O)[C@H]3O)[C@@H]2O)(O[C@@H]1[C@H](O)[C@H](O)CO)C(O)=O)O[C@H]1O[C@H](CO)[C@H](O)[C@H](O[C@@H]2O[C@@H]([C@H](O)CO)[C@H](O)[C@H]2O)[C@H]1O |r|
Structure:
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