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TargetAlpha-glucosidase A (α-Gal A)
LigandBDBM50163440
Substrate/Competitorn/a
Meas. Tech.ChEMBL_639188
IC50 70±n/a nM
Citation Kato, AYamashita, YNakagawa, SKoike, YAdachi, IHollinshead, JNash, RJIkeda, KAsano, N 2,5-Dideoxy-2,5-imino-d-altritol as a new class of pharmacological chaperone for Fabry disease. Bioorg Med Chem18:3790-4 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Alpha-glucosidase A (α-Gal A)
Name:Alpha-galactosidase A
Synonyms:Alpha-D-galactosidase A | Alpha-D-galactoside galactohydrolase | INN=Agalsidase | Melibiase
Type:Protein
Mol. Mass.:48760.21
Organism:Homo sapiens (Human)
Description:n/a
Residue:429
Sequence:
MQLRNPELHLGCALALRFLALVSWDIPGARALDNGLARTPTMGWLHWERFMCNLDCQEEP
DSCISEKLFMEMAELMVSEGWKDAGYEYLCIDDCWMAPQRDSEGRLQADPQRFPHGIRQL
ANYVHSKGLKLGIYADVGNKTCAGFPGSFGYYDIDAQTFADWGVDLLKFDGCYCDSLENL
ADGYKHMSLALNRTGRSIVYSCEWPLYMWPFQKPNYTEIRQYCNHWRNFADIDDSWKSIK
SILDWTSFNQERIVDVAGPGGWNDPDMLVIGNFGLSWNQQVTQMALWAIMAAPLFMSNDL
RHISPQAKALLQDKDVIAINQDPLGKQGYQLRQGDNFEVWERPLSGLAWAVAMINRQEIG
GPRSYTIAVASLGKGVACNPACFITQLLPVKRKLGFYEWTSRLRSHINPTGTVLLQLENT
MQMSLKDLL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50163440
NameBDBM50163440
Synonyms:(2R,3S,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-triol | (2R,3S,4R,5S)-2-Hydroxymethyl-piperidine-3,4,5-triol | 1-deoxygalactonojirimycin | CHEMBL110458 | D-galacto-1-Deoxynojirimycin | DGJ
TypeSmall organic molecule
Emp. Form.C6H13NO4
Mol. Mass.163.1717
SMILESOC[C@H]1NC[C@H](O)[C@@H](O)[C@H]1O |r|
Structure
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n/a