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Target
Glycogen synthase kinase-3 beta
Ligand
BDBM50322824
Substrate
n/a
Meas. Tech.
ChEMBL_644429 (CHEMBL1211213)
IC50
>20000±n/a nM
Citation
 Ibrahim, N; Mouawad, L; Legraverend, M Novel 8-arylated purines as inhibitors of glycogen synthase kinase. Eur J Med Chem 45:3389-93 (2010) [PubMed]  Article 
Target
Name:
Glycogen synthase kinase-3 beta
Synonyms:
GSK-3 beta | GSK-3, beta | GSK3B | GSK3B_HUMAN | Glycogen synthase kinase 3 beta (GSK3B) | Glycogen synthase kinase 3-beta (GSK3B) | Glycogen synthase kinase-3 beta (GSK-3B) | Glycogen synthase kinase-3 beta (GSK3 Beta) | Glycogen synthase kinase-3 beta (GSK3B) | Glycogen synthase kinase-3B (GSK-3B) | Glycogen synthase kinase-3beta (GSK3B) | Serine/threonine-protein kinase GSK3B
Type:
Enzyme
Mol. Mass.:
46756.38
Organism:
Homo sapiens (Human)
Description:
P49841
Residue:
420
Sequence:
MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST
  
Inhibitor
Name:
BDBM50322824
Synonyms:
CHEMBL1210477 | N-(8-(naphthalen-2-yl)-9H-purin-6-yl)pentanamide
Type:
Small organic molecule
Emp. Form.:
C20H19N5O
Mol. Mass.:
345.3978
SMILES:
CCCCC(=O)Nc1ncnc2nc([nH]c12)-c1ccc2ccccc2c1
Structure:
Search PDB for entries with ligand similarity: