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Target
Neuropeptide S receptor
Ligand
BDBM50322837
Substrate
n/a
Meas. Tech.
ChEMBL_644490 (CHEMBL1211328)
IC50
14±n/a nM
Citation
 Melamed, JY; Zartman, AE; Kett, NR; Gotter, AL; Uebele, VN; Reiss, DR; Condra, CL; Fandozzi, C; Lubbers, LS; Rowe, BA; McGaughey, GB; Henault, M; Stocco, R; Renger, JJ; Hartman, GD; Bilodeau, MT; Trotter, BW Synthesis and evaluation of a new series of Neuropeptide S receptor antagonists. Bioorg Med Chem Lett 20:4700-3 (2010) [PubMed]  Article 
Target
Name:
Neuropeptide S receptor
Synonyms:
GPR154 | GPRA | NPSR1 | NPSR1_HUMAN | PGR14
Type:
PROTEIN
Mol. Mass.:
42692.30
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1276607
Residue:
371
Sequence:
MPANFTEGSFDSSGTGQTLDSSPVACTETVTFTEVVEGKEWGSFYYSFKTEQLITLWVLFVFTIVGNSVVLFSTWRRKKKSRMTFFVTQLAITDSFTGLVNILTDINWRFTGDFTAPDLVCRVVRYLQVVLLYASTYVLVSLSIDRYHAIVYPMKFLQGEKQARVLIVIAWSLSFLFSIPTLIIFGKRTLSNGEVQCWALWPDDSYWTPYMTIVAFLVYFIPLTIISIMYGIVIRTIWIKSKTYETVISNCSDGKLCSSYNRGLISKAKIKAIKYSIIIILAFICCWSPYFLFDILDNFNLLPDTQERFYASVIIQNLPALNSAINPLIYCVFSSSISFPCREQRSQDSRMTFRERTERHEMQILSKPEFI
  
Inhibitor
Name:
BDBM50322837
Synonyms:
CHEMBL1210311 | rac-N-(1-(4-fluoropiperidin-1-yl)-3-methylpentan-3-yl)-N-((1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)cyclohexanecarboxamide
Type:
Small organic molecule
Emp. Form.:
C29H42FN3O2
Mol. Mass.:
483.6611
SMILES:
CCC(C)(CCN1CCC(F)CC1)N(Cc1cc2ccccc2n(C)c1=O)C(=O)C1CCCCC1
Structure:
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