Reaction Details Report a problem with these data
Target
Muscarinic acetylcholine receptor M4
Ligand
BDBM50323693
Substrate
n/a
Meas. Tech.
ChEMBL_648978 (CHEMBL1218676)
EC50
1300±n/a nM
Citation
 Shirey, JK; Xiang, Z; Orton, D; Brady, AE; Johnson, KA; Williams, R; Ayala, JE; Rodriguez, AL; Wess, J; Weaver, D; Niswender, CM; Conn, PJ An allosteric potentiator of M4 mAChR modulates hippocampal synaptic transmission. Nat Chem Biol 4:42-50 (2007) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M4
Synonyms:
ACM4_RAT | Cholinergic, muscarinic M4 | Chrm-4 | Chrm4
Type:
Enzyme Catalytic Domain
Mol. Mass.:
52841.70
Organism:
RAT
Description:
Cholinergic, muscarinic M4 CHRM4 RAT::P08485
Residue:
477
Sequence:
MNFTPVNGSSANQSVRLVTAAHNHLETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLGCADLIIGAFSMNLYTLYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKTLAFLKSPLMKPSIKKPPPGGASREELRNGKLEEAPPPALPPPPRPVPDKDTSNESSSGSATQNTKERPPTELSTAEATTPALPAPTLQPRTLNPASKWSKIQIVTKQTGNECVTAIEIVPATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSCIPERVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR
  
Inhibitor
Name:
BDBM50323693
Synonyms:
3-amino-N-benzyl-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide | CHEMBL1212983 | cid_734373
Type:
Small organic molecule
Emp. Form.:
C17H17N3OS
Mol. Mass.:
311.401
SMILES:
Cc1cc(C)c2c(N)c(sc2n1)C(=O)NCc1ccccc1
Structure:
Search PDB for entries with ligand similarity: