Reaction Details Report a problem with these data
Target
Dipeptidyl peptidase 9
Ligand
BDBM50324503
Substrate
n/a
Meas. Tech.
ChEMBL_649274 (CHEMBL1218972)
Ki
5.6±n/a nM
Citation
 Meng, W; Brigance, RP; Chao, HJ; Fura, A; Harrity, T; Marcinkeviciene, J; O'Connor, SP; Tamura, JK; Xie, D; Zhang, Y; Klei, HE; Kish, K; Weigelt, CA; Turdi, H; Wang, A; Zahler, R; Kirby, MS; Hamann, LG Discovery of 6-(aminomethyl)-5-(2,4-dichlorophenyl)-7-methylimidazo[1,2-a]pyrimidine-2-carboxamides as potent, selective dipeptidyl peptidase-4 (DPP4) inhibitors. J Med Chem 53:5620-8 (2010) [PubMed]  Article 
Target
Name:
Dipeptidyl peptidase 9
Synonyms:
DPP9 | DPP9_HUMAN | DPRP-2 | DPRP2 | Dipeptidyl peptidase 9 (DDP9) | Dipeptidyl peptidase 9 (DPP-9) | Dipeptidyl peptidase 9 (DPP9) | Dipeptidyl peptidase IV-related protein 2 | Dipeptidyl peptidase IX | Dipeptidyl peptidase IX (DDP-IX) | Dipeptidyl peptidase-like protein 9
Type:
Enzyme
Mol. Mass.:
98260.70
Organism:
Homo sapiens (Human)
Description:
Q86TI2
Residue:
863
Sequence:
MATTGTPTADRGDAAATDDPAARFQVQKHSWDGLRSIIHGSRKYSGLIVNKAPHDFQFVQKTDESGPHSHRLYYLGMPYGSRENSLLYSEIPKKVRKEALLLLSWKQMLDHFQATPHHGVYSREEELLRERKRLGVFGITSYDFHSESGLFLFQASNSLFHCRDGGKNGFMVSPMKPLEIKTQCSGPRMDPKICPADPAFFSFINNSDLWVANIETGEERRLTFCHQGLSNVLDDPKSAGVATFVIQEEFDRFTGYWWCPTASWEGSEGLKTLRILYEEVDESEVEVIHVPSPALEERKTDSYRYPRTGSKNPKIALKLAEFQTDSQGKIVSTQEKELVQPFSSLFPKVEYIARAGWTRDGKYAWAMFLDRPQQWLQLVLLPPALFIPSTENEEQRLASARAVPRNVQPYVVYEEVTNVWINVHDIFYPFPQSEGEDELCFLRANECKTGFCHLYKVTAVLKSQGYDWSEPFSPGEDEFKCPIKEEIALTSGEWEVLARHGSKIWVNEETKLVYFQGTKDTPLEHHLYVVSYEAAGEIVRLTTPGFSHSCSMSQNFDMFVSHYSSVSTPPCVHVYKLSGPDDDPLHKQPRFWASMMEAASCPPDYVPPEIFHFHTRSDVRLYGMIYKPHALQPGKKHPTVLFVYGGPQVQLVNNSFKGIKYLRLNTLASLGYAVVVIDGRGSCQRGLRFEGALKNQMGQVEIEDQVEGLQFVAEKYGFIDLSRVAIHGWSYGGFLSLMGLIHKPQVFKVAIAGAPVTVWMAYDTGYTERYMDVPENNQHGYEAGSVALHVEKLPNEPNRLLILHGFLDENVHFFHTNFLVSQLIRAGKPYQLQIYPNERHSIRCPESGEHYEVTLLHFLQEYL
  
Inhibitor
Name:
BDBM50324503
Synonyms:
6-(aminomethyl)-5-(2,4-dichlorophenyl)-7-methyl-N-(thiophen-2-ylmethyl)imidazo[1,2-a]pyrimidine-2-carboxamide | CHEMBL1215235
Type:
Small organic molecule
Emp. Form.:
C20H17Cl2N5OS
Mol. Mass.:
446.353
SMILES:
Cc1nc2nc(cn2c(c1CN)-c1ccc(Cl)cc1Cl)C(=O)NCc1cccs1 |(7.53,-1.38,;6.23,-2.19,;4.87,-1.48,;3.57,-2.29,;2.09,-1.85,;1.23,-3.12,;2.17,-4.34,;3.62,-3.82,;4.97,-4.55,;6.27,-3.74,;7.64,-4.46,;8.94,-3.65,;4.94,-6.08,;3.58,-6.82,;3.55,-8.36,;4.88,-9.16,;4.84,-10.7,;6.23,-8.41,;6.25,-6.87,;7.6,-6.13,;-.32,-3.16,;-1.13,-1.86,;-1.04,-4.53,;-2.58,-4.57,;-3.39,-3.26,;-4.93,-3.29,;-5.44,-1.83,;-4.21,-.9,;-2.95,-1.78,)|
Structure:
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