Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 2A
Ligand
BDBM50324543
Substrate
n/a
Meas. Tech.
ChEMBL_649396 (CHEMBL1219094)
Ki
155±n/a nM
Citation
 Xiong, Y; Ullman, B; Choi, JS; Cherrier, M; Strah-Pleynet, S; Decaire, M; Dosa, PI; Feichtinger, K; Teegarden, BR; Frazer, JM; Yoon, WH; Shan, Y; Whelan, K; Hauser, EK; Grottick, AJ; Semple, G; Al-Shamma, H Synthesis and in vivo evaluation of phenethylpiperazine amides: selective 5-hydroxytryptamine(2A) receptor antagonists for the treatment of insomnia. J Med Chem 53:5696-706 (2010) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 2A
Synonyms:
5-HT-2 | 5-HT-2A | 5-HT2A | 5-hydroxytryptamine receptor 2A (5-HT-2A) | 5-hydroxytryptamine receptor 2A (5HT-2A) | 5-hydroxytryptamine receptor 2A (5HT2A) | 5HT2A_HUMAN | HTR2 | HTR2A | Serotonin receptor 2A
Type:
undefined
Mol. Mass.:
52607.65
Organism:
Homo sapiens (Human)
Description:
P28223
Residue:
471
Sequence:
MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV
  
Inhibitor
Name:
BDBM50324543
Synonyms:
CHEMBL1215725 | N-[3-(4-Chloro-1-methyl-1H-pyrazol-5-yl)-4-methoxyphenyl]-4-(4-fluorophenethyl)piperazine-1-carboxamide
Type:
Small organic molecule
Emp. Form.:
C24H27ClFN5O2
Mol. Mass.:
471.955
SMILES:
COc1ccc(NC(=O)N2CCN(CCc3ccc(F)cc3)CC2)cc1-c1c(Cl)cnn1C |(-7.16,5.97,;-7.15,4.43,;-5.82,3.66,;-4.5,4.43,;-3.16,3.67,;-3.15,2.12,;-1.82,1.35,;-.48,2.12,;-.49,3.66,;.85,1.35,;2.17,2.13,;3.51,1.35,;3.51,-.19,;4.84,-.96,;6.17,-.19,;7.5,-.97,;8.82,-.21,;10.15,-.97,;10.15,-2.52,;11.48,-3.29,;8.82,-3.29,;7.49,-2.51,;2.17,-.96,;.84,-.19,;-4.49,1.35,;-5.82,2.12,;-7.16,1.35,;-7.09,-.18,;-5.81,-1.03,;-8.54,-.72,;-9.49,.49,;-8.64,1.77,;-9.17,3.22,)|
Structure:
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