Reaction Details
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Monocarboxylate transporter 1
Ligand
BDBM50324668
Substrate
n/a
Meas. Tech.
ChEMBL_653483 (CHEMBL1226686)
Ki
23±n/a nM
Citation
Murray, CM; Hutchinson, R; Bantick, JR; Belfield, GP; Benjamin, AD; Brazma, D; Bundick, RV; Cook, ID; Craggs, RI; Edwards, S; Evans, LR; Harrison, R; Holness, E; Jackson, AP; Jackson, CG; Kingston, LP; Perry, MW; Ross, AR; Rugman, PA; Sidhu, SS; Sullivan, M; Taylor-Fishwick, DA; Walker, PC; Whitehead, YM; Wilkinson, DJ; Wright, A; Donald, DK Monocarboxylate transporter MCT1 is a target for immunosuppression. Nat Chem Biol 1:371-6 (2005) [PubMed] Article More Info.:
Target
Name:
Monocarboxylate transporter 1
Synonyms:
MCT 1 | MCT1 | MOT1_HUMAN | Monocarboxylate transporter 1 | SLC16A1 | Solute carrier family 16 member 1
Type:
PROTEIN
Mol. Mass.:
53956.64
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1451367
Residue:
500
Sequence:
MPPAVGGPVGYTPPDGGWGWAVVIGAFISIGFSYAFPKSITVFFKEIEGIFHATTSEVSWISSIMLAVMYGGGPISSILVNKYGSRIVMIVGGCLSGCGLIAASFCNTVQQLYVCIGVIGGLGLAFNLNPALTMIGKYFYKRRPLANGLAMAGSPVFLCTLAPLNQVFFGIFGWRGSFLILGGLLLNCCVAGALMRPIGPKPTKAGKDKSKASLEKAGKSGVKKDLHDANTDLIGRHPKQEKRSVFQTINQFLDLTLFTHRGFLLYLSGNVIMFFGLFAPLVFLSSYGKSQHYSSEKSAFLLSILAFVDMVARPSMGLVANTKPIRPRIQYFFAASVVANGVCHMLAPLSTTYVGFCVYAGFFGFAFGWLSSVLFETLMDLVGPQRFSSAVGLVTIVECCPVLLGPPLLGRLNDMYGDYKYTYWACGVVLIISGIYLFIGMGINYRLLAKEQKANEQKKESKEEETSIDVAGKPNEVTKAAESPDQKDTDGGPKEEESPV
Inhibitor
Name:
BDBM50324668
Synonyms:
6-[[4-azido-3-(iodo-125I)phenyl]methyl]-2,6-dihydro-2-methyl-4-(2-methylpropyl)-1H-pyrrolo[3,4-d]pyridazin-1-one | CHEMBL1221509
Type:
Small organic molecule
Emp. Form.:
C18H19IN6O
Mol. Mass.:
462.2875
SMILES:
CC(C)Cc1nn(C)c(=O)c2cn(Cc3ccc(N=[N+]=[N-])c(I)c3)cc12
Structure:
