Reaction Details
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Monocarboxylate transporter 1
Ligand
BDBM22002
Substrate
n/a
Meas. Tech.
ChEMBL_653482 (CHEMBL1226685)
Ki
0.354813±n/a nM
Citation
Murray, CM; Hutchinson, R; Bantick, JR; Belfield, GP; Benjamin, AD; Brazma, D; Bundick, RV; Cook, ID; Craggs, RI; Edwards, S; Evans, LR; Harrison, R; Holness, E; Jackson, AP; Jackson, CG; Kingston, LP; Perry, MW; Ross, AR; Rugman, PA; Sidhu, SS; Sullivan, M; Taylor-Fishwick, DA; Walker, PC; Whitehead, YM; Wilkinson, DJ; Wright, A; Donald, DK Monocarboxylate transporter MCT1 is a target for immunosuppression. Nat Chem Biol 1:371-6 (2005) [PubMed] Article More Info.:
Target
Name:
Monocarboxylate transporter 1
Synonyms:
MCT 1 | MCT1 | MOT1_HUMAN | Monocarboxylate transporter 1 | SLC16A1 | Solute carrier family 16 member 1
Type:
PROTEIN
Mol. Mass.:
53956.64
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1451367
Residue:
500
Sequence:
MPPAVGGPVGYTPPDGGWGWAVVIGAFISIGFSYAFPKSITVFFKEIEGIFHATTSEVSWISSIMLAVMYGGGPISSILVNKYGSRIVMIVGGCLSGCGLIAASFCNTVQQLYVCIGVIGGLGLAFNLNPALTMIGKYFYKRRPLANGLAMAGSPVFLCTLAPLNQVFFGIFGWRGSFLILGGLLLNCCVAGALMRPIGPKPTKAGKDKSKASLEKAGKSGVKKDLHDANTDLIGRHPKQEKRSVFQTINQFLDLTLFTHRGFLLYLSGNVIMFFGLFAPLVFLSSYGKSQHYSSEKSAFLLSILAFVDMVARPSMGLVANTKPIRPRIQYFFAASVVANGVCHMLAPLSTTYVGFCVYAGFFGFAFGWLSSVLFETLMDLVGPQRFSSAVGLVTIVECCPVLLGPPLLGRLNDMYGDYKYTYWACGVVLIISGIYLFIGMGINYRLLAKEQKANEQKKESKEEETSIDVAGKPNEVTKAAESPDQKDTDGGPKEEESPV
Inhibitor
Name:
BDBM22002
Synonyms:
5-[(3-hydroxypropyl)sulfanyl]-3-methyl-1-(2-methylpropyl)-6-{[2-(trifluoromethyl)phenyl]methyl}-1H,2H,3H,4H-thieno[2,3-d]pyrimidine-2,4-dione | Thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione, 4
Type:
Small organic molecule
Emp. Form.:
C22H25F3N2O3S2
Mol. Mass.:
486.571
SMILES:
CC(C)Cn1c2sc(Cc3ccccc3C(F)(F)F)c(SCCCO)c2c(=O)n(C)c1=O
Structure:
