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Target
Caspase-1
Ligand
BDBM50324960
Substrate
n/a
Meas. Tech.
ChEMBL_651545 (CHEMBL1227797)
Ki
1.26±n/a nM
Citation
 Galatsis, P; Caprathe, B; Gilmore, J; Thomas, A; Linn, K; Sheehan, S; Harter, W; Kostlan, C; Lunney, E; Stankovic, C; Rubin, J; Brady, K; Allen, H; Talanian, R Succinic acid amides as P2-P3 replacements for inhibitors of interleukin-1beta converting enzyme (ICE or caspase 1). Bioorg Med Chem Lett 20:5184-90 (2010) [PubMed]  Article 
Target
Name:
Caspase-1
Synonyms:
CASP1 | CASP1_HUMAN | Caspase | Caspase 1 | ICE | IL1BC | IL1BCE | Interleukin-1 beta convertase | Interleukin-1 beta-converting enzyme
Type:
Enzyme
Mol. Mass.:
45154.13
Organism:
Homo sapiens (Human)
Description:
P29466
Residue:
404
Sequence:
MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDSVIPKGAQACQICITYICEEDSYLAGTLGLSADQTSGNYLNMQDSQGVLSSFPAPQAVQDNPAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH
  
Inhibitor
Name:
BDBM50324960
Synonyms:
(R)-2-((S)-2-isopropyl-4-oxo-4-(2-(2,5,6-trimethyl-1H-benzo[d]imidazol-1-yl)ethylamino)butanamido)-3-oxopropanoic acid | CHEMBL1221691
Type:
Small organic molecule
Emp. Form.:
C23H32N4O5
Mol. Mass.:
444.524
SMILES:
CC(C)[C@H](CC(=O)NCCn1c(C)nc2cc(C)c(C)cc12)C(=O)N[C@@H](CC(O)=O)C=O |r|
Structure:
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