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Target
Serine/threonine-protein kinase Chk1
Ligand
BDBM50325306
Substrate
n/a
Meas. Tech.
ChEMBL_651967 (CHEMBL1227640)
IC50
0.600000±n/a nM
Citation
 Hong, PC; Chen, LJ; Lai, TY; Yang, HY; Chiang, SJ; Lu, YY; Tsai, PK; Hsu, HY; Wei, WY; Liao, CB Synthesis of selenophene derivatives as novel CHK1 inhibitors. Bioorg Med Chem Lett 20:5065-8 (2010) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase Chk1
Synonyms:
CHEK1 | CHK1 | CHK1 checkpoint homolog | CHK1_HUMAN | Checkpoint kinase-1 (CHK1)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
54443.02
Organism:
Homo sapiens (Human)
Description:
gi_166295192
Residue:
476
Sequence:
MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINKMLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDFSPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLLGTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRRNNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT
  
Inhibitor
Name:
BDBM50325306
Synonyms:
CHEMBL1223407 | N-(2-(dimethylamino)ethyl)-5-((6-(4-hydroxyphenyl)-2-oxoindolin-3-ylidene)methyl)-2-methylselenophene-3-carboxamide
Type:
Small organic molecule
Emp. Form.:
C25H25N3O3Se
Mol. Mass.:
494.44
SMILES:
CN(C)CCNC(=O)c1cc(\C=C2/C(=O)Nc3cc(ccc23)-c2ccc(O)cc2)[se]c1C
Structure:
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