Reaction Details
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Ubiquitin carboxyl-terminal hydrolase isozyme L3
Ligand
BDBM50326015
Substrate
n/a
Meas. Tech.
ChEMBL_654656 (CHEMBL1243700)
IC50
47000±n/a nM
Citation
Love, KR; Catic, A; Schlieker, C; Ploegh, HL Mechanisms, biology and inhibitors of deubiquitinating enzymes. Nat Chem Biol 3:697-705 (2007) [PubMed] Article More Info.:
Target
Name:
Ubiquitin carboxyl-terminal hydrolase isozyme L3
Synonyms:
UCHL3 | UCHL3_HUMAN | Ubiquitin C-terminal Hydrolase L3 (UCH-L3) | Ubiquitin thioesterase L3
Type:
Hydrolase; protease
Mol. Mass.:
26168.69
Organism:
Homo sapiens (Human)
Description:
Human recombinant UCH-L3 was purchased from Boston Biochem, Inc.(Cambridge, MA).
Residue:
230
Sequence:
MEGQRWLPLEANPEVTNQFLKQLGLHPNWQFVDVYGMDPELLSMVPRPVCAVLLLFPITEKYEVFRTEEEEKIKSQGQDVTSSVYFMKQTISNACGTIGLIHAIANNKDKMHFESGSTLKKFLEESVSMSPEERARYLENYDAIRVTHETSAHEGQTEAPSIDEKVDLHFIALVHVDGHLYELDGRKPFPINHGETSDETLLEDAIEVCKKFMERDPDELRFNAIALSAA
Inhibitor
Name:
BDBM50326015
Synonyms:
5-(4-butylphenyl)-4-(4-isopropylphenyl)-4H-1,2,4-triazole-3-thiol | CHEMBL1241766
Type:
Small organic molecule
Emp. Form.:
C21H25N3S
Mol. Mass.:
351.508
SMILES:
CCCCc1ccc(cc1)-c1n[nH]c(=S)n1-c1ccc(cc1)C(C)C
Structure:
