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Target
Calcium/calmodulin-dependent protein kinase type II subunit delta
Ligand
BDBM50326053
Substrate
n/a
Meas. Tech.
ChEMBL_655706 (CHEMBL1244750)
Kd
36±n/a nM
Citation
 Zarrinkar, PP; Gunawardane, RN; Cramer, MD; Gardner, MF; Brigham, D; Belli, B; Karaman, MW; Pratz, KW; Pallares, G; Chao, Q; Sprankle, KG; Patel, HK; Levis, M; Armstrong, RC; James, J; Bhagwat, SS AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML). Blood 114:2984-92 (2009) [PubMed]  Article 
Target
Name:
Calcium/calmodulin-dependent protein kinase type II subunit delta
Synonyms:
CAMK2D | CAMKD | CaM kinase II | CaM kinase II delta | CaMK-II subunit delta | Calcium/calmodulin-dependent protein kinase type II subunit delta | Calcium/calmodulin-dependent protein kinase type II subunit delta (CAMK2D) | Calcium/calmodulin-dependent protein kinase type II subunit delta (CaMKII subunit delta) | KCC2D_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
56419.78
Organism:
Homo sapiens (Human)
Description:
Q13557
Residue:
499
Sequence:
MASTTTCTRFTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWICQRSTVASMMHRQETVDCLKKFNARRKLKGAILTTMLATRNFSAAKSLLKKPDGVKESTESSNTTIEDEDVKARKQEIIKVTEQLIEAINNGDFEAYTKICDPGLTAFEPEALGNLVEGMDFHRFYFENALSKSNKPIHTIILNPHVHLVGDDAACIAYIRLTQYMDGSGMPKTMQSEETRVWHRRDGKWQNVHFHRSGSPTVPIKPPCIPNGKENFSGGTSLWQNI
  
Inhibitor
Name:
BDBM50326053
Synonyms:
CHEMBL608533 | PKC-412
Type:
Small organic molecule
Emp. Form.:
C35H30N4O4
Mol. Mass.:
570.6371
SMILES:
CO[C@@H]1[C@@H](C[C@H]2O[C@]1(C)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13)N(C)C(=O)c1ccccc1 |r|
Structure:
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