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Target
Transcription factor Jun
Ligand
BDBM50326119
Substrate
n/a
Meas. Tech.
ChEMBL_657293 (CHEMBL1249120)
IC50
5700±n/a nM
Citation
 Giri, RS; Thaker, HM; Giordano, T; Chen, B; Nuthalapaty, S; Vasu, KK; Sudarsanam, V Synthesis and evaluation of quinazolinone derivatives as inhibitors of NF-kappaB, AP-1 mediated transcription and eIF-4E mediated translational activation: inhibitors of multi-pathways involve in cancer. Eur J Med Chem 45:3558-63 (2010) [PubMed]  Article 
Target
Name:
Transcription factor Jun
Synonyms:
AP1 | Activator protein 1 | JUN | JUN_HUMAN | Proto-oncogene c-JUN | Transcription factor AP-1 | Transcription factor AP1 | V-jun avian sarcoma virus 17 oncogene homolog | p39
Type:
n/a
Mol. Mass.:
35683.24
Organism:
Homo sapiens (Human)
Description:
P05412
Residue:
331
Sequence:
MTAKMETTFYDDALNASFLPSESGPYGYSNPKILKQSMTLNLADPVGSLKPHLRAKNSDLLTSPDVGLLKLASPELERLIIQSSNGHITTTPTPTQFLCPKNVTDEQEGFAEGFVRALAELHSQNTLPSVTSAAQPVNGAGMVAPAVASVAGGSGSGGFSASLHSEPPVYANLSNFNPGALSSGGGAPSYGAAGLAFPAQPQQQQQPPHHLPQQMPVQHPRLQALKEEPQTVPEMPGETPPLSPIDMESQERIKAERKRMRNRIAASKCRKRKLERIARLEEKVKTLKAQNSELASTANMLREQVAQLKQKVMNHVNSGCQLMLTQQLQTF
  
Inhibitor
Name:
BDBM50326119
Synonyms:
CHEMBL1242070 | [5-(4-Oxo-3-phenyl-3,4-dihydro-quinazolin-2-yl)-4-phenylthiazol-2-yl]-carbamic acid ethyl ester
Type:
Small organic molecule
Emp. Form.:
C26H20N4O3S
Mol. Mass.:
468.527
SMILES:
CCOC(=O)Nc1nc(c(s1)-c1nc2ccccc2c(=O)n1-c1ccccc1)-c1ccccc1
Structure:
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