Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetSolute carrier family 2, facilitated glucose transporter member 1
LigandBDBM50326284
Substrate/Competitorn/a
Meas. Tech.ChEMBL_659928
IC50>10000±n/a nM
Citation Nomura, SSakamaki, SHongu, MKawanishi, EKoga, YSakamoto, TYamamoto, YUeta, KKimata, HNakayama, KTsuda-Tsukimoto, M Discovery of canagliflozin, a novel C-glucoside with thiophene ring, as sodium-dependent glucose cotransporter 2 inhibitor for the treatment of type 2 diabetes mellitus. J Med Chem53:6355-60 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Solute carrier family 2, facilitated glucose transporter member 1
Name:Solute carrier family 2, facilitated glucose transporter member 1
Synonyms:n/a
Type:PROTEIN
Mol. Mass.:53969.94
Organism:Rattus norvegicus
Description:ChEMBL_659928
Residue:492
Sequence:
MEPSSKKVTGRLMLAVGGAVLGSLQFGYNTGVINAPQKVIEEFYNQTWNHRYGESIPSTT
LTTLWSLSVAIFSVGGMIGSFSVGLFVNRFGRRNSMLMMNLLAFVSAVLMGFSKLGKSFE
MLILGRFIIGVYCGLTTGFVPMYVGEVSPTALRGALGTLHQLGIVVGILIAQVFGLDSIM
GNADLWPLLLSVIFIPALLQCILLPFCPESPRFLLINRNEENRAKSVLKKLRGTADVTRD
LQEMKEEGRQMMREKKVTILELFRSPAYRQPILIAVVLQLSQQLSGINAVFYYSTSIFEK
AGVQQPVYATIGSGIVNTAFTVVSLFVVERAGRRTLHLIGLAGMAGCAVLMTIALALLEQ
LPWMSYLSIVAIFGFVAFFEVGPGPIPWFIVAELFSQGPRPAAVAVAGFSNWTSNFIVGM
CFQYVEQLCGPYVFIIFTVLLVLFFIFTYFKVPETKGRTFDEIASGFRQGGASQSDKTPE
ELFHPLGADSQV
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50326284
NameBDBM50326284
Synonyms:1-(beta-D-Glucopyranosyl)-4-methyl-3-(5-(4-fluorophenyl)-2-thienylmethyl)benzene | CHEMBL1243275
TypeSmall organic molecule
Emp. Form.C24H25FO6S
Mol. Mass.460.515
SMILESCc1cccc(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c1Cc1ccc(s1)-c1ccc(F)cc1 |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a