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Target
Calpain-2 catalytic subunit
Ligand
BDBM50326302
Substrate
n/a
Meas. Tech.
ChEMBL_659959 (CHEMBL1247360)
Ki
286±n/a nM
Citation
 Ovat, A; Li, ZZ; Hampton, CY; Asress, SA; Fernández, FM; Glass, JD; Powers, JC Peptidyl alpha-ketoamides with nucleobases, methylpiperazine, and dimethylaminoalkyl substituents as calpain inhibitors. J Med Chem 53:6326-36 (2010) [PubMed]  Article 
Target
Name:
Calpain-2 catalytic subunit
Synonyms:
3.4.22.53 | CAN2_PIG | CANP 2 | CAPN2 | Calcium-activated neutral proteinase 2 | Calpain 2 | Calpain M-type | Calpain-2 catalytic subunit | Calpain-2 large subunit | M-calpain | Millimolar-calpain
Type:
n/a
Mol. Mass.:
37789.71
Organism:
Sus scrofa
Description:
n/a
Residue:
324
Sequence:
YPNTFWMNPQYLIKLEEEDEDQEDGESGCTFLVGLIQKHRRRQRKMGEDMHTIGFGIYEVPEELTGQTNIHLSKNFFLTHRARERSDTFINLREVLNRFKLPPGEYILVPSTFEPNKDGDFCIRVFSEKKADYQVVDDEIEADLEENDASEDDIDDGFRRLFAQLAGEDAEISAFELQTILRRVLAKRQDIKSDGFSIETCRIMVDMLDSDGSAKLGLKEFYILWTKIQKYQKIYREIDVDRSGTMNSYEMRKALEEAGFKLPCQLHQVIVARFADDQLIIDFDNFVRCLVRLETLFRISKQLDSENTGTIELDLISWLCFSVL
  
Inhibitor
Name:
BDBM50326302
Synonyms:
3-(Benzyloxycarbonyl-L-leucylamino)-N-(3-(4-methylpiperazin-1-yl)propyl)-2-oxopentanamide | CHEMBL1242987
Type:
Small organic molecule
Emp. Form.:
C27H43N5O5
Mol. Mass.:
517.6608
SMILES:
CCC(NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1)C(=O)C(=O)NCCCN1CCN(C)CC1 |r|
Structure:
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