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Target
Serine/threonine-protein kinase Sgk1
Ligand
BDBM50298223
Substrate
n/a
Meas. Tech.
ChEMBL_657459 (CHEMBL1246571)
IC50
2700±n/a nM
Citation
 Oyarzabal, J; Zarich, N; Albarran, MI; Palacios, I; Urbano-Cuadrado, M; Mateos, G; Reymundo, I; Rabal, O; Salgado, A; Corrionero, A; Fominaya, J; Pastor, J; Bischoff, JR Discovery of mitogen-activated protein kinase-interacting kinase 1 inhibitors by a comprehensive fragment-oriented virtual screening approach. J Med Chem 53:6618-28 (2010) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase Sgk1
Synonyms:
SGK | SGK1 | SGK1_HUMAN | Serine/threonine-protein kinase Sgk1 | Serine/threonine-protein kinase Sgk1 (SGK) | Serum/glucocorticoid regulated kinase | Serum/glucocorticoid-regulated kinase 1 (SGK1)
Type:
Other Protein Type
Mol. Mass.:
48954.40
Organism:
Homo sapiens (Human)
Description:
Recombinant human SGK-1 enzyme produced in a baculovirus system.
Residue:
431
Sequence:
MTVKTEAAKGTLTYSRMRGMVAILIAFMKQRRMGLNDFIQKIANNSYACKHPEVQSILKISQPQEPELMNANPSPPPSPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPTDSFL
  
Inhibitor
Name:
BDBM50298223
Synonyms:
CGP-57380 | CHEMBL1240885 | CHEMBL576817 | N-(4-fluorophenyl)-3H-pyrazolo[3,4-d]pyrimidine-3,4-diamine
Type:
Small organic molecule
Emp. Form.:
C11H9FN6
Mol. Mass.:
244.2278
SMILES:
Nc1ncnc2n[nH]c(Nc3ccc(F)cc3)c12
Structure:
Search PDB for entries with ligand similarity: