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Target
RAC-gamma serine/threonine-protein kinase
Ligand
BDBM50326706
Substrate
n/a
Meas. Tech.
ChEMBL_662184 (CHEMBL1252175)
IC50
>10000±n/a nM
Citation
 Okuzumi, T; Fiedler, D; Zhang, C; Gray, DC; Aizenstein, B; Hoffman, R; Shokat, KM Inhibitor hijacking of Akt activation. Nat Chem Biol 5:484-93 (2009) [PubMed]  Article 
Target
Name:
RAC-gamma serine/threonine-protein kinase
Synonyms:
AKT3 | AKT3_HUMAN | PKB gamma | PKBG | Protein kinase Akt-3 | Protein kinase B (Akt 3) | Protein kinase B, gamma | RAC-PK-gamma | RAC-gamma serine/threonine-protein kinase | STK-2 | Serine/threonine-protein kinase AKT | Serine/threonine-protein kinase AKT3
Type:
Enzyme
Mol. Mass.:
55769.36
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
479
Sequence:
MSDVTIVKEGWVQKRGEYIKNWRPRYFLLKTDGSFIGYKEKPQDVDLPYPLNNFSVAKCQLMKTERPKPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAIQAVADRLQRQEEERMNCSPTSQIDNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFDEEFTAQTITITPPEKYDEDGMDCMDNERRPHFPQFSYSASGRE
  
Inhibitor
Name:
BDBM50326706
Synonyms:
(S)-1-(1H-indol-3-yl)-3-(5-(3-methyl-7-propyl-1H-indazol-5-yl)pyridin-3-yloxy)propan-2-amine | CHEMBL1254114
Type:
Small organic molecule
Emp. Form.:
C27H29N5O
Mol. Mass.:
439.5521
SMILES:
CCCc1cc(cc2c(C)n[nH]c12)-c1cncc(OC[C@@H](N)Cc2c[nH]c3ccccc23)c1 |r|
Structure:
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