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TargetEcdysone receptor
LigandBDBM50326767
Substrate/Competitorn/a
Meas. Tech.ChEMBL_661762
IC50 5500±n/a nM
Citation Birru, WFernley, RTGraham, LDGrusovin, JHill, RJHofmann, AHowell, LJames, PJJarvis, KEJohnson, WMJones, DALeitner, CLiepa, AJLovrecz, GOLu, LNearn, RHO'Driscoll, BJPhan, TPollard, MTurner, KAWinkler, DA Synthesis, binding and bioactivity of gamma-methylene gamma-lactam ecdysone receptor ligands: advantages of QSAR models for flexible receptors. Bioorg Med Chem18:5647-60 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Ecdysone receptor
Name:Ecdysone receptor
Synonyms:20-hydroxy-ecdysone receptor | 20E receptor | EcRH | Ecdysteroid receptor | Nuclear receptor subfamily 1 group H member 1
Type:PROTEIN
Mol. Mass.:82587.92
Organism:Lucilia cuprina
Description:ChEMBL_661762
Residue:757
Sequence:
MMKRRWSNNGGFAALKMLEESSSEVTSSSNGLVLSSDINMSPSSLDSPVYGDQEMWLCND
SASYNNSHQHSVITSLQGCTSSLPAQTTIIPLSALPNSNNASLNNQNQNYQNGNSMNTNL
SVNTNNSVGGGGGGGGVPGMTSLNGLGGGGGSQVNNHNHSHNHLHHNSNSNHSNSSSHHT
NGHMGIGGGGGGLSVNINGPNIVSNAQQLNSLQASQNGQVIHANIGIHSIISNGLNHHHH
HHMNNSSMMHHTPRSESANSISSGRDDLSPSSSLNGFSTSDASDVKKIKKGPAPRLQEEL
CLVCGDRASGYHYNALTCEGCKGFFRRSVTKNAVYCCKFGHACEMDMYMRRKCQECRLKK
CLAVGMRPECVVPENQCAMKRREKKAQKEKDKIQTSVCATEIKKEILDLMTCEPPSHPTC
PLLPEDILAKCQARNIPPLSYNQLAVIYKLIWYQDGYEQPSEEDLKRIMSSPDENESQHD
ASFRHITEITILTVQLIVEFAKGLPAFTKIPQEDQITLLKACSSEVMMLRMARRYDHNSD
SIFFANNRSYTRDSYKMAGMADNIEDLLHFCRQMYSMKVDNVEYALLTAIVIFSDRPGLE
EAELVEAIQSYYIDTLRIYILNRHCGDPMSLVFFAKLLSILTELRTLGNQNAEMCFSLKL
KNRKLPKFLEEIWDVHAIPPSVQSHIQATQAEKAAQEAQATTSAISAAATSSSSINTSMA
TSSSSSLSPSAASTPNGGAVDYVGTDMSMSLVQSDNA
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50326767
NameBDBM50326767
Synonyms:4-butyl-1-(2-tert-butyl-5-chlorophenyl)-5-methylene-2-oxo-2,5-dihydro-1H-pyrrole-3-carbonitrile | CHEMBL1254948
TypeSmall organic molecule
Emp. Form.C20H23ClN2O
Mol. Mass.342.862
SMILESCCCCC1=C(C#N)C(=O)N(C1=C)c1cc(Cl)ccc1C(C)(C)C |c:4|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a