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Target
Geranylgeranyl pyrophosphate synthase
Ligand
BDBM50327045
Substrate
n/a
Meas. Tech.
ChEMBL_663732 (CHEMBL1250632)
IC50
800±n/a nM
Citation
 Barney, RJ; Wasko, BM; Dudakovic, A; Hohl, RJ; Wiemer, DF Synthesis and biological evaluation of a series of aromatic bisphosphonates. Bioorg Med Chem 18:7212-20 (2010) [PubMed]  Article 
Target
Name:
Geranylgeranyl pyrophosphate synthase
Synonyms:
Dimethylallyltranstransferase | Farnesyltranstransferase | GGPP synthetase | GGPPS_HUMAN | GGPPSase | GGPS1 | Geranylgeranyl Diphosphate Synthase (GGPPS) | Geranylgeranyl diphosphate synthase | Geranylgeranyl pyrophosphate synthetase | Geranyltranstransferase
Type:
Homooctamer; transferase
Mol. Mass.:
34867.94
Organism:
Homo sapiens (Human)
Description:
Recombinant human GGPPS was cloned and expressed in E. coli.
Residue:
300
Sequence:
MEKTQETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLLELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLKPLLNTLGLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTENIDIKKYCVHYLEDVGSFEYTRNTLKELEAKAYKQIDARGGNPELVALVKHLSKMFKEENE
  
Inhibitor
Name:
BDBM50327045
Synonyms:
CHEMBL1254093 | sodium(E)-5,9-dimethyl-1-(4-(3-methylbut-2-enyl)phenyl)deca-4,8-diene-2,2-diyldiphosphonate
Type:
Small organic molecule
Emp. Form.:
C23H32O6P2
Mol. Mass.:
466.4463
SMILES:
[#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6])=[#6]\[#6]C([#6]-c1ccc(-[#6]\[#6]=[#6](\[#6])-[#6])cc1)(P([#8-])([#8-])=O)P([#8-])([#8-])=O
Structure:
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