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Target
Aldo-keto reductase family 1 member B1
Ligand
BDBM50022182
Substrate
n/a
Meas. Tech.
ChEMBL_664730 (CHEMBL1260797)
IC50
20800±n/a nM
Citation
 Kato, A; Kobayashi, K; Narukawa, K; Minoshima, Y; Adachi, I; Hirono, S; Nash, RJ 6,7-Dihydroxy-4-phenylcoumarin as inhibitor of aldose reductase 2. Bioorg Med Chem Lett 20:5630-3 (2010) [PubMed]  Article 
Target
Name:
Aldo-keto reductase family 1 member B1
Synonyms:
AKR1B1 | ALDR1 | ALDR_HUMAN | ALR2 | AR | Aldo-keto reductase family 1 member B1 (AKR1B1) | Aldose Reductase (ALR2) | Aldose reductase | Aldose reductase (AR)
Type:
Protein
Mol. Mass.:
35855.50
Organism:
Homo sapiens (Human)
Description:
P15121. 4LAU; 2IKI; 4LB4; 2FZD; 2FZ8; 1US0
Residue:
316
Sequence:
MASRLLLNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEVGVAIQEKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGKEFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLKYKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAKHNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRNWRVCALLSCTSHKDYPFHEEF
  
Inhibitor
Name:
BDBM50022182
Synonyms:
(7-Hydroxy-2-oxo-2H-chromen-4-yl)-acetic acid | 7-hydroxycoumarin-4-acetic acid | CHEMBL12253
Type:
Small organic molecule
Emp. Form.:
C11H8O5
Mol. Mass.:
220.1782
SMILES:
OC(=O)Cc1cc(=O)oc2cc(O)ccc12
Structure:
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