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Target
Sorbitol dehydrogenase
Ligand
BDBM50206007
Substrate
n/a
Meas. Tech.
ChEMBL_664732 (CHEMBL1260799)
IC50
106000±n/a nM
Citation
 Kato, A; Kobayashi, K; Narukawa, K; Minoshima, Y; Adachi, I; Hirono, S; Nash, RJ 6,7-Dihydroxy-4-phenylcoumarin as inhibitor of aldose reductase 2. Bioorg Med Chem Lett 20:5630-3 (2010) [PubMed]  Article 
Target
Name:
Sorbitol dehydrogenase
Synonyms:
DHSO_HUMAN | L-iditol 2-dehydrogenase | SORD
Type:
PROTEIN
Mol. Mass.:
38332.20
Organism:
Homo sapiens (Human)
Description:
ChEMBL_223910
Residue:
357
Sequence:
MAAAAKPNNLSLVVHGPGDLRLENYPIPEPGPNEVLLRMHSVGICGSDVHYWEYGRIGNFIVKKPMVLGHEASGTVEKVGSSVKHLKPGDRVAIEPGAPRENDEFCKMGRYNLSPSIFFCATPPDDGNLCRFYKHNAAFCYKLPDNVTFEEGALIEPLSVGIHACRRGGVTLGHKVLVCGAGPIGMVTLLVAKAMGAAQVVVTDLSATRLSKAKEIGADLVLQISKESPQEIARKVEGQLGCKPEVTIECTGAEASIQAGIYATRSGGNLVLVGLGSEMTTVPLLHAAIREVDIKGVFRYCNTWPVAISMLASKSVNVKPLVTHRFPLEKALEAFETFKKGLGLKIMLKCDPSDQNP
  
Inhibitor
Name:
BDBM50206007
Synonyms:
3-Hydroxy-chromen-2-one | 3-hydroxy-2H-chromen-2-one | CHEMBL150372
Type:
Small organic molecule
Emp. Form.:
C9H6O3
Mol. Mass.:
162.1421
SMILES:
Oc1cc2ccccc2oc1=O
Structure:
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