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Target
Sorbitol dehydrogenase
Ligand
BDBM34571
Substrate
n/a
Meas. Tech.
ChEMBL_664732 (CHEMBL1260799)
IC50
82900±n/a nM
Citation
 Kato, A; Kobayashi, K; Narukawa, K; Minoshima, Y; Adachi, I; Hirono, S; Nash, RJ 6,7-Dihydroxy-4-phenylcoumarin as inhibitor of aldose reductase 2. Bioorg Med Chem Lett 20:5630-3 (2010) [PubMed]  Article 
Target
Name:
Sorbitol dehydrogenase
Synonyms:
DHSO_HUMAN | L-iditol 2-dehydrogenase | SORD
Type:
PROTEIN
Mol. Mass.:
38332.20
Organism:
Homo sapiens (Human)
Description:
ChEMBL_223910
Residue:
357
Sequence:
MAAAAKPNNLSLVVHGPGDLRLENYPIPEPGPNEVLLRMHSVGICGSDVHYWEYGRIGNFIVKKPMVLGHEASGTVEKVGSSVKHLKPGDRVAIEPGAPRENDEFCKMGRYNLSPSIFFCATPPDDGNLCRFYKHNAAFCYKLPDNVTFEEGALIEPLSVGIHACRRGGVTLGHKVLVCGAGPIGMVTLLVAKAMGAAQVVVTDLSATRLSKAKEIGADLVLQISKESPQEIARKVEGQLGCKPEVTIECTGAEASIQAGIYATRSGGNLVLVGLGSEMTTVPLLHAAIREVDIKGVFRYCNTWPVAISMLASKSVNVKPLVTHRFPLEKALEAFETFKKGLGLKIMLKCDPSDQNP
  
Inhibitor
Name:
BDBM34571
Synonyms:
6,7-bis(oxidanyl)chromen-2-one | 6,7-dihydroxy-1-benzopyran-2-one | 6,7-dihydroxychromen-2-one | CHEMBL244743 | MLS000069479 | SMR000059055 | cid_5281416 | esculetin
Type:
Small organic molecule
Emp. Form.:
C9H6O4
Mol. Mass.:
178.1415
SMILES:
Oc1cc2ccc(=O)oc2cc1O
Structure:
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