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Target
Proline-rich AKT1 substrate 1
Ligand
BDBM50327797
Substrate
n/a
Meas. Tech.
ChEMBL_664853 (CHEMBL1259577)
IC50
1500±n/a nM
Citation
 Blake, JF; Kallan, NC; Xiao, D; Xu, R; Bencsik, JR; Skelton, NJ; Spencer, KL; Mitchell, IS; Woessner, RD; Gloor, SL; Risom, T; Gross, SD; Martinson, M; Morales, TH; Vigers, GP; Brandhuber, BJ Discovery of pyrrolopyrimidine inhibitors of Akt. Bioorg Med Chem Lett 20:5607-12 (2010) [PubMed]  Article 
Target
Name:
Proline-rich AKT1 substrate 1
Synonyms:
40 kDa proline-rich AKT substrate | AKT1S1 | AKTS1_HUMAN | PRAS40
Type:
PROTEIN
Mol. Mass.:
27368.40
Organism:
Homo sapiens (Human)
Description:
ChEMBL_664853
Residue:
256
Sequence:
MASGRPEELWEAVVGAAERFRARTGTELVLLTAAPPPPPRPGPCAYAAHGRGALAEAARRCLHDIALAHRAATAARPPAPPPAPQPPSPTPSPPRPTLAREDNEEDEDEPTETETSGEQLGISDNGGLFVMDEDATLQDLPPFCESDPESTDDGSLSEETPAGPPTCSVPPASALPTQQYAKSLPVSVPVWGFKEKRTEARSSDEENGPPSSPDLDRIAASMRALVLREAEDTQVFGDLPRPRLNTSDFQKLKRKY
  
Inhibitor
Name:
BDBM50327797
Synonyms:
(R)-2-amino-3-(4-chlorophenyl)-1-(4-(quinazolin-4-yl)piperazin-1-yl)propan-1-one | CHEMBL1258330
Type:
Small organic molecule
Emp. Form.:
C21H22ClN5O
Mol. Mass.:
395.885
SMILES:
N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(CC1)c1ncnc2ccccc12 |r|
Structure:
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