Target
Malonyl-CoA decarboxylase, mitochondrial
Ligand
BDBM50328226
Substrate
n/a
Meas. Tech.
ChEMBL_665404 (CHEMBL1261133)
IC50
1.6±n/a nM
Citation
 Tang, HYan, YFeng, Zde Jesus, RKYang, LLevorse, DAOwens, KAAkiyama, TEBergeron, RCastriota, GADoebber, TWEllsworth, KPLassman, MELi, CWu, MSZhang, BBChapman, KTMills, SGBerger, JPPasternak, A Design and synthesis of a new class of malonyl-CoA decarboxylase inhibitors with anti-obesity and anti-diabetic activities. Bioorg Med Chem Lett 20:6088-92 (2010) [PubMed]  Article 
Target
Name:
Malonyl-CoA decarboxylase, mitochondrial
Synonyms:
DCMC_HUMAN | MLYCD | Malonyl-CoA decarboxylase
Type:
PROTEIN
Mol. Mass.:
55018.37
Organism:
Homo sapiens (Human)
Description:
ChEMBL_665404
Residue:
493
Sequence:
MRGFGPGLTARRLLPLRLPPRPPGPRLASGQAAGALERAMDELLRRAVPPTPAYELREKTPAPAEGQCADFVSFYGGLAETAQRAELLGRLARGFGVDHGQVAEQSAGVLHLRQQQREAAVLLQAEDRLRYALVPRYRGLFHHISKLDGGVRFLVQLRADLLEAQALKLVEGPDVREMNGVLKGMLSEWFSSGFLNLERVTWHSPCEVLQKISEAEAVHPVKNWMDMKRRVGPYRRCYFFSHCSTPGEPLVVLHVALTGDISSNIQAIVKEHPPSETEEKNKITAAIFYSISLTQQGLQGVELGTFLIKRVVKELQREFPHLGVFSSLSPIPGFTKWLLGLLNSQTKEHGRNELFTDSECKEISEITGGPINETLKLLLSSSEWVQSEKLVRALQTPLMRLCAWYLYGEKHRGYALNPVANFHLQNGAVLWRINWMADVSLRGITGSCGLMANYRYFLEETGPNSTSYLGSKIIKASEQVLSLVAQFQKNSKL
  
Inhibitor
Name:
BDBM50328226
Synonyms:
2-(2-(4-(3-(1H-tetrazol-5-yl)phenyl)piperazin-1-yl)thiazol-5-yl)-1,1,1,3,3,3-hexafluoropropan-2-ol | CHEMBL1258935
Type:
Small organic molecule
Emp. Form.:
C17H15F6N7OS
Mol. Mass.:
479.403
SMILES:
OC(c1cnc(s1)N1CCN(CC1)c1cccc(c1)-c1nnn[nH]1)(C(F)(F)F)C(F)(F)F
Structure:
Search PDB for entries with ligand similarity: