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Target
Beta-3 adrenergic receptor
Ligand
BDBM50328334
Substrate
n/a
Meas. Tech.
ChEMBL_665493 (CHEMBL1261324)
Ki
11±n/a nM
Citation
 Tasler, S; Baumgartner, R; Ammendola, A; Schachtner, J; Wieber, T; Blisse, M; Rath, S; Zaja, M; Klahn, P; Quotschalla, U; Ney, P Thienopyrimidines asß3-adrenoceptor agonists: hit-to-lead optimization. Bioorg Med Chem Lett 20:6108-15 (2010) [PubMed]  Article 
Target
Name:
Beta-3 adrenergic receptor
Synonyms:
ADRB3 | ADRB3R | ADRB3_HUMAN | B3AR | Beta-2 adrenergic receptor and beta-3 adrenergic receptor | Beta-3 adrenoceptor | Beta-3 adrenoreceptor | adrenergic Beta3
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
43534.88
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
408
Sequence:
MAPWPHENSSLAPWPDLPTLAPNTANTSGLPGVPWEAALAGALLALAVLATVGGNLLVIVAIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRVGADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRGELGRFPPEESPPAPSRSLAPAPVGTCAPPEGVPACGRRPARLLPLREHRALCTLGLIMGTFTLCWLPFFLANVLRALGGPSLVPGPAFLALNWLGYANSAFNPLIYCRSPDFRSAFRRLLCRCGRRLPPEPCAAARPALFPSGVPAARSSPAQPRLCQRLDGASWGVS
  
Inhibitor
Name:
BDBM50328334
Synonyms:
1-(2-methoxyphenoxy)-3-(1-(5-phenylthieno[2,3-d]pyrimidin-4-yl)piperidin-4-ylamino)propan-2-ol | CHEMBL1258023
Type:
Small organic molecule
Emp. Form.:
C27H30N4O3S
Mol. Mass.:
490.617
SMILES:
COc1ccccc1OCC(O)CNC1CCN(CC1)c1ncnc2scc(-c3ccccc3)c12
Structure:
Search PDB for entries with ligand similarity: