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Target
Histone deacetylase 7
Ligand
BDBM19410
Substrate
n/a
Meas. Tech.
ChEMBL_672865 (CHEMBL1267840)
IC50
>100000±n/a nM
Citation
 Hutt, DM; Herman, D; Rodrigues, AP; Noel, S; Pilewski, JM; Matteson, J; Hoch, B; Kellner, W; Kelly, JW; Schmidt, A; Thomas, PJ; Matsumura, Y; Skach, WR; Gentzsch, M; Riordan, JR; Sorscher, EJ; Okiyoneda, T; Yates, JR; Lukacs, GL; Frizzell, RA; Manning, G; Gottesfeld, JM; Balch, WE Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis. Nat Chem Biol 6:25-33 (2009) [PubMed]  Article 
Target
Name:
Histone deacetylase 7
Synonyms:
HD7 | HDAC7 | HDAC7A | HDAC7_HUMAN | Histone acetylase 7 (HDAC7) | Histone deacetylase 7A | Human HDAC7
Type:
Chromatin regulator; hydrolase; repressor
Mol. Mass.:
102942.62
Organism:
Homo sapiens (Human)
Description:
Q8WUI4
Residue:
952
Sequence:
MDLRVGQRPPVEPPPEPTLLALQRPQRLHHHLFLAGLQQQRSVEPMRLSMDTPMPELQVGPQEQELRQLLHKDKSKRSAVASSVVKQKLAEVILKKQQAALERTVHPNSPGIPYRTLEPLETEGATRSMLSSFLPPVPSLPSDPPEHFPLRKTVSEPNLKLRYKPKKSLERRKNPLLRKESAPPSLRRRPAETLGDSSPSSSSTPASGCSSPNDSEHGPNPILGSEALLGQRLRLQETSVAPFALPTVSLLPAITLGLPAPARADSDRRTHPTLGPRGPILGSPHTPLFLPHGLEPEAGGTLPSRLQPILLLDPSGSHAPLLTVPGLGPLPFHFAQSLMTTERLSGSGLHWPLSRTRSEPLPPSATAPPPPGPMQPRLEQLKTHVQVIKRSAKPSEKPRLRQIPSAEDLETDGGGPGQVVDDGLEHRELGHGQPEARGPAPLQQHPQVLLWEQQRLAGRLPRGSTGDTVLLPLAQGGHRPLSRAQSSPAAPASLSAPEPASQARVLSSSETPARTLPFTTGLIYDSVMLKHQCSCGDNSRHPEHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQSVHSERHVLLYGTNPLSRLKLDNGKLAGLLAQRMFVMLPCGGVGVDTDTIWNELHSSNAARWAAGSVTDLAFKVASRELKNGFAVVRPPGHHADHSTAMGFCFFNSVAIACRQLQQQSKASKILIVDWDVHHGNGTQQTFYQDPSVLYISLHRHDDGNFFPGSGAVDEVGAGSGEGFNVNVAWAGGLDPPMGDPEYLAAFRIVVMPIAREFSPDLVLVSAGFDAAEGHPAPLGGYHVSAKCFGYMTQQLMNLAGGAVVLALEGGHDLTAICDASEACVAALLGNRVDPLSEEGWKQKPNLNAIRSLEAVIRVHSKYWGCMQRLASCPDSWVPRVPGADKEEVEAVTALASLSVGILAEDRPSEQLVEEEEPMNL
  
Inhibitor
Name:
BDBM19410
Synonyms:
CHEMBL27759 | MS-275 | US11377423, MS-275 | US11672788, Compound Entinostat | US9265734, MS-275 | US9796664, Compound MS-275 | benzamide-type inhibitor, 3 | pyridin-3-ylmethyl N-({4-[(2-aminophenyl)carbamoyl]phenyl}methyl)carbamate
Type:
Small organic molecule
Emp. Form.:
C21H20N4O3
Mol. Mass.:
376.4085
SMILES:
Nc1ccccc1NC(=O)c1ccc(CNC(=O)OCc2cccnc2)cc1
Structure:
Search PDB for entries with ligand similarity: