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Target
Protein arginine N-methyltransferase 1 [11-371]
Ligand
BDBM50328745
Substrate
n/a
Meas. Tech.
ChEMBL_675347 (CHEMBL1273384)
IC50
68200±n/a nM
Citation
 Feng, Y; Li, M; Wang, B; Zheng, YG Discovery and mechanistic study of a class of protein arginine methylation inhibitors. J Med Chem 53:6028-39 (2010) [PubMed]  Article 
Target
Name:
Protein arginine N-methyltransferase 1 [11-371]
Synonyms:
ANM1_HUMAN | HMT2 | HRMT1L2 | IR1B4 | PRMT1 | Protein arginine N-methyltransferase 1 (PRMT1) | Protein arginine methyltransferase 1 (PRMT1) | Protein-arginine N-methyltransferase 1
Type:
Protein
Mol. Mass.:
41506.52
Organism:
Homo sapiens (Human)
Description:
Q99873[11-371]
Residue:
361
Sequence:
MENFVATLANGMSLQPPLEEVSCGQAESSEKPNAEDMTSKDYYFDSYAHFGIHEEMLKDEVRTLTYRNSMFHNRHLFKDKVVLDVGSGTGILCMFAAKAGARKVIGIECSSISDYAVKIVKANKLDHVVTIIKGKVEEVELPVEKVDIIISEWMGYCLFYESMLNTVLYARDKWLAPDGLIFPDRATLYVTAIEDRQYKDYKIHWWENVYGFDMSCIKDVAIKEPLVDVVDPKQLVTNACLIKEVDIYTVKVEDLTFTSPFCLQVKRNDYVHALVAYFNIEFTRCHKRTGFSTSPESPYTHWKQTVFYMEDYLTVKTGEEIFGTIGMRPNAKNNRDLDFTIDLDFKGQLCELSCSTDYRMR
  
Inhibitor
Name:
BDBM50328745
Synonyms:
4,5-dihydroxy-3-((8-hydroxy-3,6-disulfonatonaphthalen-1-yl)diazenyl)naphthalene-2,7-disulfonate | 4,5-dihydroxy-3-(8-hydroxy-3,6-disulfo-naphthalen-1-ylazo)-naphthalene-2,7-disulfonic acid | CHEMBL409290
Type:
Small organic molecule
Emp. Form.:
C20H14N2O15S4
Mol. Mass.:
650.59
SMILES:
Oc1cc(cc2cc(c(N=Nc3cc(cc4cc(cc(O)c34)S(O)(=O)=O)S(O)(=O)=O)c(O)c12)S(O)(=O)=O)S(O)(=O)=O |w:10.10|
Structure:
Search PDB for entries with ligand similarity: