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Target
Renin
Ligand
BDBM50328923
Substrate
n/a
Meas. Tech.
ChEMBL_673988 (CHEMBL1275165)
IC50
0.1±n/a nM
Citation
 Corminboeuf, O; Bezençon, O; Remen, L; Grisostomi, C; Richard-Bildstein, S; Bur, D; Prade, L; Strickner, P; Hess, P; Fischli, W; Steiner, B; Treiber, A Piperidine-based renin inhibitors: upper chain optimization. Bioorg Med Chem Lett 20:6291-6 (2010) [PubMed]  Article 
Target
Name:
Renin
Synonyms:
Angiotensinogenase | REN | RENI_HUMAN
Type:
Enzyme
Mol. Mass.:
45058.99
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
406
Sequence:
MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEWSQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
  
Inhibitor
Name:
BDBM50328923
Synonyms:
5-chloro-4-(((3R,4S)-N-cyclopropyl-4-(6-((S)-3-(2,6-dichloro-4-methylphenoxy)pyrrolidin-1-yl)pyridin-3-yl)piperidine-3-carboxamido)methyl)-2-(3-methoxypropyl)pyridine 1-oxide | CHEMBL1269761
Type:
Small organic molecule
Emp. Form.:
C35H42Cl3N5O4
Mol. Mass.:
703.098
SMILES:
COCCCc1cc(CN(C2CC2)C(=O)[C@H]2CNCC[C@@H]2c2ccc(nc2)N2CC[C@@H](C2)Oc2c(Cl)cc(C)cc2Cl)c(Cl)c[n+]1[O-] |r|
Structure:
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