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Target1,4-Dihydroxy-2-naphthoyl-CoA synthase
LigandBDBM50329082
Substrate/Competitorn/a
Meas. Tech.ChEMBL_674193
IC50 24100±n/a nM
Citation Li, XLiu, NZhang, HKnudson, SESlayden, RATonge, PJ Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. Bioorg Med Chem Lett20:6306-9 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
1,4-Dihydroxy-2-naphthoyl-CoA synthase
Name:1,4-Dihydroxy-2-naphthoyl-CoA synthase
Synonyms:DHNA-CoA synthase
Type:PROTEIN
Mol. Mass.:34688.06
Organism:Mycobacterium tuberculosis
Description:ChEMBL_817596
Residue:314
Sequence:
MVAPAGEQGRSSTALSDNPFDAKAWRLVDGFDDLTDITYHRHVDDATVRVAFNRPEVRNA
FRPHTVDELYRVLDHARMSPDVGVVLLTGNGPSPKDGGWAFCSGGDQRIRGRSGYQYASG
DTADTVDVARAGRLHILEVQRLIRFMPKVVICLVNGWAAGGGHSLHVVCDLTLASREYAR
FKQTDADVGSFDGGYGSAYLARQVGQKFAREIFFLGRTYTAEQMHQMGAVNAVAEHAELE
TVGLQWAAEINAKSPQAQRMLKFAFNLLDDGLVGQQLFAGEATRLAYMTDEAVEGRDAFL
QKRPPDWSPFPRYF
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  Blast E-value cutoff:
BDBM50329082
NameBDBM50329082
Synonyms:(Z)-methyl 2-(5-methyl-2-oxo-2H-benzo[b][1,4]oxazin-3(4H)-ylidene)acetate | CHEMBL1269381
TypeSmall organic molecule
Emp. Form.C12H11NO4
Mol. Mass.233.22
SMILESCOC(=O)Cc1nc2c(C)cccc2oc1=O
Structure
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n/a