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TargetCalcitonin gene-related peptide type 1 receptor
LigandBDBM50329174
Substrate/Competitorn/a
Meas. Tech.ChEMBL_674593
Ki 0.037±n/a nM
Citation Wood, MRSchirripa, KMKim, JJBednar, RAFay, JFBruno, JGMoore, ELMosser, SDRoller, SSalvatore, CAVacca, JPSelnick, HG Novel CGRP receptor antagonists from central amide replacements causing a reversal of preferred chirality. Bioorg Med Chem Lett20:6827-30 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Calcitonin gene-related peptide type 1 receptor
Name:Adrenomedullin receptor AM1; CALCRL/RAMP2
Synonyms:Calcitonin gene-related peptide (CGRP) receptor | Calcitonin gene-related peptide 1 (CGRP) | Calcitonin receptor-like receptor
Type:Enzyme
Mol. Mass.:52931.38
Organism:Homo sapiens (Human)
Description:Q16602
Residue:461
Sequence:
MEKKCTLNFLVLLPFFMILVTAELEESPEDSIQLGVTRNKIMTAQYECYQKIMQDPIQQA
EGVYCNRTWDGWLCWNDVAAGTESMQLCPDYFQDFDPSEKVTKICDQDGNWFRHPASNRT
WTNYTQCNVNTHEKVKTALNLFYLTIIGHGLSIASLLISLGIFFYFKSLSCQRITLHKNL
FFSFVCNSVVTIIHLTAVANNQALVATNPVSCKVSQFIHLYLMGCNYFWMLCEGIYLHTL
IVVAVFAEKQHLMWYYFLGWGFPLIPACIHAIARSLYYNDNCWISSDTHLLYIIHGPICA
ALLVNLFFLLNIVRVLITKLKVTHQAESNLYMKAVRATLILVPLLGIEFVLIPWRPEGKI
AEEVYDYIMHILMHFQGLLVSTIFCFFNGEVQAILRRNWNQYKIQFGNSFSNSEALRSAS
YTVSTISDGPGYSHDCPSEHLNGKSIHDIENVLLKPENLYN
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BDBM50329174
NameBDBM50329174
Synonyms:CHEMBL1269644 | N-(((R)-2,3-dihydro-1H-inden-1-yl)methyl)-N-(((S)-2'-oxo-1',2',6,8-tetrahydrospiro[cyclopenta[g]quinoline-7,3'-pyrrolo[2,3-b]pyridine]-3-yl)methyl)pivalamide
TypeSmall organic molecule
Emp. Form.C34H34N4O2
Mol. Mass.530.6594
SMILESCC(C)(C)C(=O)N(C[C@@H]1CCc2ccccc12)Cc1cnc2cc3C[C@]4(Cc3cc2c1)C(=O)Nc1ncccc41 |r|
Structure
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