Target
Bcl-2-like protein 1
Ligand
BDBM50329368
Substrate
n/a
Meas. Tech.
ChEMBL_675632 (CHEMBL1273940)
Kd
450000±n/a nM
Citation
 Petros, AMHuth, JROost, TPark, CMDing, HWang, XZhang, HNimmer, PMendoza, RSun, CMack, JWalter, KDorwin, SGramling, ELadror, URosenberg, SHElmore, SWFesik, SWHajduk, PJ Discovery of a potent and selective Bcl-2 inhibitor using SAR by NMR. Bioorg Med Chem Lett 20:6587-91 (2010) [PubMed]  Article 
Target
Name:
Bcl-2-like protein 1
Synonyms:
Anti-apoptotic Bcl-2 protein | Apoptosis Regulator Bcl-xL | Apoptosis regulator Bcl-X | B2CL1_HUMAN | BCL2-like 1 isoform 1 | BCL2L | BCL2L1 | BCLX | Bcl-2-like protein 1 (Bcl-XL) | Bcl-X | Bcl-xL/Bcl-2-binding component 3 | Bcl2-L-1 | Bcl2-antagonist of cell death (BAD)
Type:
Mitochondrion membrane; Single-pass membrane protein
Mol. Mass.:
26039.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
233
Sequence:
MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLADSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
  
Inhibitor
Name:
BDBM50329368
Synonyms:
1,1-bis(4-chlorophenyl)-4-(dimethylamino)butan-1-ol | CHEMBL1270616
Type:
Small organic molecule
Emp. Form.:
C18H21Cl2NO
Mol. Mass.:
338.271
SMILES:
CN(C)CCCC(O)(c1ccc(Cl)cc1)c1ccc(Cl)cc1
Structure:
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