| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Retinoid X receptor gamma/retinoic acid receptor alpha |
|---|
| Ligand | BDBM50061625 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_674528 |
|---|
| EC50 | 45±n/a nM |
|---|
| Citation |  Vizirianakis, IS; Chatzopoulou, M; Bonovolias, ID; Nicolaou, I; Demopoulos, VJ; Tsiftsoglou, AS Toward the development of innovative bifunctional agents to induce differentiation and to promote apoptosis in leukemia: clinical candidates and perspectives. J Med Chem53:6779-810 (2010) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Retinoid X receptor gamma/retinoic acid receptor alpha |
|---|
| Name: | Retinoic acid receptor alpha/Retinoid X receptor alpha |
|---|
| Synonyms: | Nuclear receptor subfamily 1 group B member 1 | RAR-alpha | Retinoic acid receptor alpha |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 50778.87 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1466191 |
|---|
| Residue: | 462 |
|---|
| Sequence: | MASNSSSCPTPGGGHLNGYPVPPYAFFFPPMLGGLSPPGALTTLQHQLPVSGYSTPSPAT
IETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNM
VYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEVPKPECSESYTL
TPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTV
EFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNA
GFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALK
VYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGL
DTLSGQPGGGGRDGGGLAPPPGSCSPSLSPSSNRSSPATHSP
|
|
|
|---|
| BDBM50061625 |
|---|
| Name | BDBM50061625 |
|---|
| Synonyms: | 4-[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbamoyl]benzoic acid | Am 80 | CHEMBL25202 | Tamibarotene | US9963439, AM80 | retinobenzoic acid |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H25NO3 |
|---|
| Mol. Mass. | 351.4388 |
|---|
| SMILES | CC1(C)CCC(C)(C)c2cc(NC(=O)c3ccc(cc3)C(O)=O)ccc12 |
|---|
| Structure |  |
|---|
| n/a |
|---|
Search and Browse
