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Target
Bcl-2-related protein A1
Ligand
BDBM50313353
Substrate
n/a
Meas. Tech.
ChEMBL_676083 (CHEMBL1273077)
IC50
1900±n/a nM
Citation
 Cashman, JR; MacDonald, M; Ghirmai, S; Okolotowicz, KJ; Sergienko, E; Brown, B; Garcia, X; Zhai, D; Dahl, R; Reed, JC Inhibition of Bfl-1 with N-aryl maleimides. Bioorg Med Chem Lett 20:6560-4 (2010) [PubMed]  Article 
Target
Name:
Bcl-2-related protein A1
Synonyms:
B2LA1_HUMAN | BCL2A1 | BCL2L5 | BFL1 | Bcl-2-like protein 5 | GRS | HBPA1 | Hemopoietic-specific early response protein | Protein BFL-1 | Protein GRS
Type:
Apoptosis regulator protein
Mol. Mass.:
20130.01
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
175
Sequence:
MTDCEFGYIYRLAQDYLQCVLQIPQPGSGPSKTSRVLQNVAFSVQKEVEKNLKSCLDNVNVVSVDTARTLFNQVMEKEFEDGIINWGRIVTIFAFEGILIKKLLRQQIAPDVDTYKEISYFVAEFIMNNTGEWIRQNGGWENGFVKKFEPKSGWMTFLEVTGKICEMLSLLKQYC
  
Inhibitor
Name:
BDBM50313353
Synonyms:
6-(cyclohexyl(cyclopropylmethyl)amino)-N-(6-methyl-1H-indazol-5-yl)pyrimidine-4-carboxamide | CHEMBL1080382 | US9150519, 1-47
Type:
Small organic molecule
Emp. Form.:
C23H28N6O
Mol. Mass.:
404.508
SMILES:
Cc1cc2[nH]ncc2cc1NC(=O)c1cc(ncn1)N(CC1CC1)C1CCCCC1
Structure:
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