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TargetBeta-lactamase SHV-11
LigandBDBM50021954
Substrate/Competitorn/a
Meas. Tech.ChEMBL_679490
IC50 2400±n/a nM
Citation Dubois, VPoirel, LDemarthe, FArpin, CCoulange, LMinarini, LABezian, MCNordmann, PQuentin, C Molecular and biochemical characterization of SHV-56, a novel inhibitor-resistant beta-lactamase from Klebsiella pneumoniae. Antimicrob Agents Chemother52:3792-4 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Beta-lactamase SHV-11
Name:Beta-lactamase SHV-11
Synonyms:SHV type extended spectrum beta-lactamase
Type:PROTEIN
Mol. Mass.:31241.65
Organism:Escherichia coli
Description:ChEMBL_679490
Residue:286
Sequence:
MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRADE
RFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCA
AAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPA
SMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKTGAGERGARG
IVALLGPNNKAERIVVIYLRDTPASMAERNQQIAGIGAALIEHWQR
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  Blast E-value cutoff:
BDBM50021954
NameBDBM50021954
Synonyms:(2S,5R)-3,3-Dimethyl-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid | (S)-3,3-Dimethyl-7-(R)-oxo-4,4-dioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid | 3,3-Dimethyl-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid | 3,3-Dimethyl-4,4,7-trioxo-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid (Sulbactam) | CHEMBL403 | CP-45,899 | SULBACTAM | UNASYN | US9120808, Sulbactam sodium salt
TypeSmall organic molecule
Emp. Form.C8H11NO5S
Mol. Mass.233.242
SMILESCC1(C)[C@@H](N2[C@@H](CC2=O)S1(=O)=O)C(O)=O |r|
Structure
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