Reaction Details Report a problem with these data
Target
Purine nucleoside phosphorylase
Ligand
BDBM50078082
Substrate
n/a
Meas. Tech.
ChEMBL_684503 (CHEMBL1287512)
IC50
>1000000±n/a nM
Citation
 Cui, H; Ruda, GF; Carrero-Lérida, J; Ruiz-Pérez, LM; Gilbert, IH; González-Pacanowska, D Exploring new inhibitors of Plasmodium falciparum purine nucleoside phosphorylase. Eur J Med Chem 45:5140-9 (2010) [PubMed]  Article 
Target
Name:
Purine nucleoside phosphorylase
Synonyms:
Purine Nucleoside Phosphorylase (PNP) | pfPNP
Type:
Enzyme
Mol. Mass.:
26857.85
Organism:
Plasmodium falciparum
Description:
n/a
Residue:
245
Sequence:
MDNLLRHLKISKEQITPVVLVVGDPGRVDKIKVVCDSYVDLAYNREYKSVECHYKGQKFLCVSHGVGSAGCAVCFEELCQNGAKVIIRAGSCGSLQPDLIKRGDICICNAAVREDRVSHLLIHGDFPAVGDFDVYDTLNKCAQELNVPVFNGISVSSDMYYPNKIIPSRLEDYSKANAAVVEMELATLMVIGTLRKVKTGGILIVDGCPFKWDEGDFDNNLVPHQLENMIKIALGACAKLATKYA
  
Inhibitor
Name:
BDBM50078082
Synonyms:
5-(3-Benzyloxy-benzyl)-pyrimidine-2,4,6-trione | CHEMBL37519
Type:
Small organic molecule
Emp. Form.:
C18H16N2O4
Mol. Mass.:
324.3306
SMILES:
Oc1[nH]c(=O)[nH]c(=O)c1Cc1cccc(OCc2ccccc2)c1
Structure:
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