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TargetFructose-1,6-bisphosphate aldolase (FBA)
LigandBDBM50330433
Substrate/Competitorn/a
Meas. Tech.ChEMBL_684842
IC50 3.2±n/a nM
Citation Daher, RCoinçon, MFonvielle, MGest, PMGuerin, MEJackson, MSygusch, JTherisod, M Rational design, synthesis, and evaluation of new selective inhibitors of microbial class II (zinc dependent) fructose bis-phosphate aldolases. J Med Chem53:7836-42 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Fructose-1,6-bisphosphate aldolase (FBA)
Name:Fructose-1,6-bisphosphate aldolase (FBA)
Synonyms:FBP aldolase | FBPA | Fructose-1,6-bisphosphate aldolase | Fructose-bisphosphate aldolase | Probable fructose-bisphosphate aldolase Fba
Type:Protein
Mol. Mass.:36539.01
Organism:Mycobacterium tuberculosis (strain H37Rv)
Description:P9WQA3
Residue:344
Sequence:
MPIATPEVYAEMLGQAKQNSYAFPAINCTSSETVNAAIKGFADAGSDGIIQFSTGGAEFG
SGLGVKDMVTGAVALAEFTHVIAAKYPVNVALHTDHCPKDKLDSYVRPLLAISAQRVSKG
GNPLFQSHMWDGSAVPIDENLAIAQELLKAAAAAKIILEIEIGVVGGEEDGVANEINEKL
YTSPEDFEKTIEALGAGEHGKYLLAATFGNVHGVYKPGNVKLRPDILAQGQQVAAAKLGL
PADAKPFDFVFHGGSGSLKSEIEEALRYGVVKMNVDTDTQYAFTRPIAGHMFTNYDGVLK
VDGEVGVKKVYDPRSYLKKAEASMSQRVVQACNDLHCAGKSLTH
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  Blast E-value cutoff:
BDBM50330433
NameBDBM50330433
Synonyms:4-{hydroxy[(phosphonooxy)acetyl]amino}butyl dihydrogen phosphate | CHEMBL1236228 | N-(4-hydroxybutyl)-glycolohydroxamicacid bis-phosphate
TypeSmall organic molecule
Emp. Form.C6H15NO10P2
Mol. Mass.323.1315
SMILESON(CCCCOP(O)(O)=O)C(=O)COP(O)(O)=O
Structure
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n/a