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TargetFructose-1,6-bisphosphate aldolase (FBA)
LigandBDBM50330437
Substrate/Competitorn/a
Meas. Tech.ChEMBL_684842
Ki 21000±n/a nM
Citation Daher, RCoinçon, MFonvielle, MGest, PMGuerin, MEJackson, MSygusch, JTherisod, M Rational design, synthesis, and evaluation of new selective inhibitors of microbial class II (zinc dependent) fructose bis-phosphate aldolases. J Med Chem53:7836-42 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Fructose-1,6-bisphosphate aldolase (FBA)
Name:Fructose-1,6-bisphosphate aldolase (FBA)
Synonyms:FBP aldolase | FBPA | Fructose-1,6-bisphosphate aldolase | Fructose-bisphosphate aldolase | Probable fructose-bisphosphate aldolase Fba
Type:Protein
Mol. Mass.:36539.01
Organism:Mycobacterium tuberculosis (strain H37Rv)
Description:P9WQA3
Residue:344
Sequence:
MPIATPEVYAEMLGQAKQNSYAFPAINCTSSETVNAAIKGFADAGSDGIIQFSTGGAEFG
SGLGVKDMVTGAVALAEFTHVIAAKYPVNVALHTDHCPKDKLDSYVRPLLAISAQRVSKG
GNPLFQSHMWDGSAVPIDENLAIAQELLKAAAAAKIILEIEIGVVGGEEDGVANEINEKL
YTSPEDFEKTIEALGAGEHGKYLLAATFGNVHGVYKPGNVKLRPDILAQGQQVAAAKLGL
PADAKPFDFVFHGGSGSLKSEIEEALRYGVVKMNVDTDTQYAFTRPIAGHMFTNYDGVLK
VDGEVGVKKVYDPRSYLKKAEASMSQRVVQACNDLHCAGKSLTH
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  Blast E-value cutoff:
BDBM50330437
NameBDBM50330437
Synonyms:1,6-di-O-phosphono-D-fructose | 2,3,4-trihydroxy-5-oxohexane-1,6-diyl bis(dihydrogen phosphate) | CHEMBL1235112
TypeSmall organic molecule
Emp. Form.C6H14O12P2
Mol. Mass.340.1157
SMILESOC(COP(O)(O)=O)[C@@H](O)C(=O)[C@H](O)COP(O)(O)=O |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
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